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Record W4406045880 · doi:10.1101/2025.01.03.631238

Visual field specializations in mouse dLGN

2025· preprint· en· W4406045880 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2025
Typepreprint
Languageen
FieldEngineering
TopicRobotics and Automated Systems
Canadian institutionsMcGill University
Fundersnot available
KeywordsField (mathematics)Computer sciencePsychologyHuman–computer interactionMathematics

Abstract

fetched live from OpenAlex

Abstract Neural circuits throughout the visual system process features differently depending on where they appear in the visual field. While such location-specific processing exists in retina and in superior colliculus, the dorsal lateral geniculate nucleus (dLGN) is thought to lack this specialization. Here, we show systematic visual field biases in dLGN’s representation of spatial frequency, orientation, direction, and temporal frequency. Using axon-localized calcium indicators and widefield imaging, we discovered that dLGN boutons show systematic gradients in feature selectivity across the visual cortex (V1), while its retinal inputs lack such gradients for these features. Selective disruption of V1 feedback to dLGN perturbed gradient structure and magnitude. These results suggest that dLGN circuits transform uniformly distributed retinal feature inputs into spatially-biased representations along with cortical feedback. dLGN feature biases would allow a functional stream to detect ethologically salient visual inputs.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.074
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.001
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.221
Teacher spread0.211 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it