Finding Reproducible and Prognostic Radiomic Features in Variable Slice Thickness Contrast Enhanced CT of Colorectal Liver Metastases
Why this work is in the frame
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Bibliographic record
Abstract
Establishing the reproducibility of radiomic signatures is a critical step in the path to clinical adoption of quantitative imaging biomarkers; however, radiomic signatures must also be meaningfully related to an outcome of clinical importance to be of value for personalized medicine. In this study, we analyze both the reproducibility and prognostic value of radiomic features extracted from the liver parenchyma and largest liver metastases in contrast enhanced CT scans of patients with colorectal liver metastases (CRLM). A prospective cohort of 81 patients from two major US cancer centers was used to establish the reproducibility of radiomic features extracted from images reconstructed with different slice thicknesses. A publicly available, single-center cohort of 197 preoperative scans from patients who underwent hepatic resection for treatment of CRLM was used to evaluate the prognostic value of features and models to predict overall survival. A standard set of 93 features was extracted from all images, with a set of eight different extractor settings. The feature extraction settings producing the most reproducible, as well as the most prognostically discriminative feature values were highly dependent on both the region of interest and the specific feature in question. While the best overall predictive model was produced using features extracted with a particular setting, without accounting for reproducibility, (C-index = 0.630 (0.603-0.649)) an equivalent-performing model (C-index = 0.629 (0.605-0.645)) was produced by pooling features from all extraction settings, and thresholding features with low reproducibility (CCC ≥ 0.85), prior to feature selection. Our findings support a data-driven approach to feature extraction and selection, preferring the inclusion of many features, and narrowing feature selection based on reproducibility when relevant data is available.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.006 | 0.009 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it