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Record W4406864562 · doi:10.1016/j.csbj.2025.01.007

Interpretability of AI race detection model in medical imaging with saliency methods

2025· article· en· W4406864562 on OpenAlexafffund
Salamata Konate, Léo Lebrat, Rodrigo Santa Cruz, Judy Wawira Gichoya, Brandon Price, Laleh Seyyed-Kalantari, Clinton Fookes, Andrew P. Bradley, Olivier Salvado

Bibliographic record

VenueComputational and Structural Biotechnology Journal · 2025
Typearticle
Languageen
FieldComputer Science
TopicExplainable Artificial Intelligence (XAI)
Canadian institutionsVector InstituteYork University
FundersCooperative Research Centres, Australian Government Department of IndustryCanada First Research Excellence FundCommonwealth Scientific and Industrial Research OrganisationYork University
KeywordsInterpretabilityRace (biology)Artificial intelligenceComputer scienceComputational biologyMachine learningPattern recognition (psychology)Biology

Abstract

fetched live from OpenAlex

Deep neural networks (DNNs) are powerful tools for classifying images. Using these convolutional models for medical images is challenging due to their complexity and large number of parameters, making it hard to find clinically meaningful explanations for their decisions. To overcome the opaqueness inherent to such models, saliency techniques suggest generating maps that highlight the regions of an image important for the DNN's prediction. DNN models have shown the capability of race detection from medical images of different modalities, which is concerning as they under-diagnose patients from historically under-served races. The objective of this paper is to use explainability methods to detect subtle bias that DNNs use to detect a patient's race from chest X-rays. Toward this end, we apply eight state-of-the-art methods and propose to evaluate their effectiveness. We demonstrate that the salient region's size is crucial to understanding network behavior. When the salient region covers 30% of the image, we find that only the Rise method is effective at locating salient areas, as it can both accurately predict a patient's race on chest X-ray images on its own and mislead the network on race detection when removed. We, therefore, note that saliency maps in the medical field should be used with caution, as there is no available ground truth, and the network may occasionally employ low-level image features to compute predictions.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.005
Threshold uncertainty score0.010

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.005
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0010.000
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.328
Teacher spread0.320 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2025
Admission routes2
Has abstractyes

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