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Record W4406864562 · doi:10.1016/j.csbj.2025.01.007

Interpretability of AI race detection model in medical imaging with saliency methods

2025· article· en· W4406864562 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueComputational and Structural Biotechnology Journal · 2025
Typearticle
Languageen
FieldComputer Science
TopicExplainable Artificial Intelligence (XAI)
Canadian institutionsVector InstituteYork University
FundersCooperative Research Centres, Australian Government Department of IndustryCanada First Research Excellence FundCommonwealth Scientific and Industrial Research OrganisationYork University
KeywordsInterpretabilityRace (biology)Artificial intelligenceComputer scienceComputational biologyMachine learningPattern recognition (psychology)Biology

Abstract

fetched live from OpenAlex

Deep neural networks (DNNs) are powerful tools for classifying images. Using these convolutional models for medical images is challenging due to their complexity and large number of parameters, making it hard to find clinically meaningful explanations for their decisions. To overcome the opaqueness inherent to such models, saliency techniques suggest generating maps that highlight the regions of an image important for the DNN's prediction. DNN models have shown the capability of race detection from medical images of different modalities, which is concerning as they under-diagnose patients from historically under-served races. The objective of this paper is to use explainability methods to detect subtle bias that DNNs use to detect a patient's race from chest X-rays. Toward this end, we apply eight state-of-the-art methods and propose to evaluate their effectiveness. We demonstrate that the salient region's size is crucial to understanding network behavior. When the salient region covers 30% of the image, we find that only the Rise method is effective at locating salient areas, as it can both accurately predict a patient's race on chest X-ray images on its own and mislead the network on race detection when removed. We, therefore, note that saliency maps in the medical field should be used with caution, as there is no available ground truth, and the network may occasionally employ low-level image features to compute predictions.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.790
Threshold uncertainty score0.334

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.328
Teacher spread0.320 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it