Identifying texture features from structural magnetic resonance imaging scans associated with Tourette’s syndrome using machine learning
Bibliographic record
Abstract
Purpose: Tourette syndrome (TS) is a neurodevelopmental disorder characterized by neurophysiological and neuroanatomical changes, primarily affecting individuals aged 2 to 18. Involuntary motor and vocal tics are common features of this syndrome. Currently, there is no curative therapy for TS, only psychological treatments or medications that temporarily manage the tics. The absence of a definitive diagnostic tool complicates the differentiation of TS from other neurological and psychological conditions. Approach: We aim to enhance the diagnosis of TS through the classification of structural magnetic resonance scans. Our methodology comprises four sequential steps: (1) image acquisition, data were generated for the National Taiwan University, composing images of pediatric magnetic resonance imaging (MRI); (2) pre-processing, involving anatomical structural segmentation using reesurfer software; (3) feature extraction, where texture features in volumetric images are obtained; and (4) image classification, employing support vector machine and naive Bayes classifiers to determine the presence of TS. Results: The analysis indicated significant changes in the regions of the limbic system, such as the thalamus and amygdala, and regions outside the limbic system such as medial orbitofrontal cortex and insula, which are strongly associated with TS. Conclusions: Our findings suggest that texture features derived from sMRI scans can aid in the diagnosis of TS by highlighting critical brain regions involved in the disorder. The proposed method holds promise for improving diagnostic accuracy and understanding the neuroanatomical underpinnings of TS.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.003 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".