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Record W4408104839 · doi:10.1016/j.jpi.2025.100434

Custom R Flexdashboard for molecular genetic pathology quality tracking

2025· article· en· W4408104839 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
aboutThe title or abstract carries a Canadian signal from the geographic lexicon.

Bibliographic record

VenueJournal of Pathology Informatics · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGene expression and cancer classification
Canadian institutionsSt. Michael's HospitalUniversity of Toronto
Fundersnot available
KeywordsComputer scienceMolecular pathologyQuality (philosophy)Digital pathologyComputational biologyBioinformaticsPathologyBiologyArtificial intelligenceMedicineGeneticsGene

Abstract

fetched live from OpenAlex

The practice of modern-day laboratory medicine entails extensive, daily practice of tracking various quality metrics of every molecular test to ensure quality maintenance, as well as for laboratory management. While various third-party tools are commercially available, they represent a significant investment for publicly funded institutions. To automate aspects of this quality management, we developed a custom dashboard, written using R. We used R Studio, a freely available software, and employed the Shiny and Flexdashboard packages to develop the code base for the dashboard. Data for the dashboard were pulled from multiple Excel tracking spreadsheets for different clinical assays. The current dashboard allows for dynamic, automated reporting of case volume, and turn-around time, which are regularly reported metrics to CancerCare Ontario for reimbursement purposes. Workload tracking is also made possible, automating calculations regularly performed for billing purposes. The dashboard summarizes various quality metrics for each assay in a single table, viewable by multiple personnel within a single network. Additional features such as filtering quality metrics by date and customization of a variety of plots were also included. Whereas other informatics solutions may be available, our custom solution represents a low-cost system that alleviates a significant workload from various members of the laboratory medicine department, easing the currently significant administrative burden from the “hands-on” staff. Future work will be focused on further improving the accessibility of the dashboard and the integration of additional molecular assays for quality monitoring.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.312
Threshold uncertainty score0.495

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.018
GPT teacher head0.334
Teacher spread0.316 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it