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Record W4408104839 · doi:10.1016/j.jpi.2025.100434

Custom R Flexdashboard for molecular genetic pathology quality tracking

2025· article· en· W4408104839 on OpenAlexaffabout
Steven S. Shen, Ju‐Yoon Yoon

Bibliographic record

VenueJournal of Pathology Informatics · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGene expression and cancer classification
Canadian institutionsSt. Michael's HospitalUniversity of Toronto
Fundersnot available
KeywordsComputer scienceMolecular pathologyQuality (philosophy)Digital pathologyComputational biologyBioinformaticsPathologyBiologyArtificial intelligenceMedicineGeneticsGene

Abstract

fetched live from OpenAlex

The practice of modern-day laboratory medicine entails extensive, daily practice of tracking various quality metrics of every molecular test to ensure quality maintenance, as well as for laboratory management. While various third-party tools are commercially available, they represent a significant investment for publicly funded institutions. To automate aspects of this quality management, we developed a custom dashboard, written using R. We used R Studio, a freely available software, and employed the Shiny and Flexdashboard packages to develop the code base for the dashboard. Data for the dashboard were pulled from multiple Excel tracking spreadsheets for different clinical assays. The current dashboard allows for dynamic, automated reporting of case volume, and turn-around time, which are regularly reported metrics to CancerCare Ontario for reimbursement purposes. Workload tracking is also made possible, automating calculations regularly performed for billing purposes. The dashboard summarizes various quality metrics for each assay in a single table, viewable by multiple personnel within a single network. Additional features such as filtering quality metrics by date and customization of a variety of plots were also included. Whereas other informatics solutions may be available, our custom solution represents a low-cost system that alleviates a significant workload from various members of the laboratory medicine department, easing the currently significant administrative burden from the “hands-on” staff. Future work will be focused on further improving the accessibility of the dashboard and the integration of additional molecular assays for quality monitoring.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.007
metaresearch head score (Gemma)0.027
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Software · Consensus signal: Software
Teacher disagreement score0.088
Threshold uncertainty score0.296

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0070.027
Meta-epidemiology (narrow)0.0030.002
Meta-epidemiology (broad)0.0020.002
Bibliometrics0.0030.002
Science and technology studies0.0010.001
Scholarly communication0.0040.003
Open science0.0030.003
Research integrity0.0010.003
Insufficient payload (model declined to judge)0.0880.050

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.018
GPT teacher head0.334
Teacher spread0.316 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreSoftware

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes2
Has abstractyes

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