Treatment With Schistosoma Japonicum Peptide SJMHE1 and SJMHE1-Loaded Hydrogel for the Mitigation of Psoriasis
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The three-model screen
all 1,000 screened works →All three models called this out of scope.
Preclinical peptide and hydrogel treatment for psoriasis; a therapeutic efficacy question.
The study tests a therapeutic intervention for psoriasis rather than research practice.
Preclinical psoriasis treatment with a schistosome peptide hydrogel; biomedical therapeutics.
Abstract
Purpose: ) on the inflammatory response in imiquimod (IMQ)-induced psoriasis mice and LPS-stimulated keratinocytes, as well as the efficacy of SJMHE1-loaded hydrogel on psoriasis in mice. Methods: SJMHE1 was administered to mice with IMQ-induced psoriasis via topical administration or subcutaneous injection, and effects were evaluated by detecting the skin inflammation of mice. LPS-stimulated HaCaT cells were used to assess the regulatory effects of SJMHE1 in vitro. Additionally, the effects of Poloxamer 407 (P407)-loaded SJMHE1 were evaluated in mice with IMQ-induced psoriasis through topical application. Results: Topical administration and subcutaneous injection of SJMHE1 alleviated psoriasis-like skin lesions, improved PASI scores, reduced epidermal thickness and dermal inflammatory cell infiltration, and decreased expression of Ki67, a marker of keratinocyte proliferation or differentiation. SJMHE1 modulated pro-inflammatory and anti-inflammatory cytokine expression in LPS-treated HaCaT cells, down-regulating NF-κB and STAT3 activation. Both SJMHE1-loaded hydrogel and SJMHE1 treatment alleviated IMQ-induced psoriasis-like skin lesions, improved PASI scores, reduced the number of Ki67-positive epidermal cells, decreased the spleen index and T-cell infiltration, increased the proportion of regulatory T cells (Tregs), and decreased the percentage of Th17 cells, alongside reducing inflammatory cytokine expression and NF-κB and STAT3 activation in skin lesions. Notably, weight changes in the SJMHE1-loaded gel group were less than those in the betamethasone-positive control group on days 6, 7, and 8 post-IMQ administration. Conclusion: SJMHE1-loaded hydrogel and SJMHE1 treatment inhibited NF-κB and STAT3 activation in skin lesions, improved Th17/Treg balance, and reduced inflammatory cytokine expression in psoriasis mice, thereby ameliorating psoriatic lesion symptoms. Furthermore, SJMHE1-loaded hydrogel exhibited fewer side effects compared to betamethasone, positioning it as a promising strategy against psoriasis.
Stored with the screening record, where it is evidence for the labels above.
The record
- Venue
- Psoriasis Targets and Therapy
- Topic
- Psoriasis: Treatment and Pathogenesis
- Field
- Immunology and Microbiology
- Canadian institutions
- Magna International (Canada)
- Funders
- —
- Keywords
- Schistosoma japonicumPeptidePsoriasisSelf-healing hydrogelsChemistryNanotechnologyMaterials scienceBiophysicsSchistosomiasisBiologyHelminthsImmunologyBiochemistryPolymer chemistry
- Has abstract in OpenAlex
- yes