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Record W4411056120 · doi:10.1371/journal.pdig.0000866

The illusion of safety: A report to the FDA on AI healthcare product approvals

2025· article· en· W4411056120 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenuePLOS Digital Health · 2025
Typearticle
Languageen
FieldMedicine
TopicArtificial Intelligence in Healthcare and Education
Canadian institutionsNorth York General HospitalUniversity of Toronto
FundersNational Science Foundation
KeywordsTransparency (behavior)Health careAccountabilityCompromiseRisk analysis (engineering)Food and drug administrationBusinessComputer scienceKnowledge managementComputer securityEconomicsPolitical science

Abstract

fetched live from OpenAlex

Artificial intelligence is rapidly transforming healthcare, offering promising advancements in diagnosis, treatment, and patient outcomes. However, concerns regarding the regulatory oversight of artificial intelligence driven medical technologies have emerged, particularly with the U.S. Food and Drug Administration's current approval processes. This paper critically examines the U.S. Food and Drug Administration's regulatory framework for artificial intelligence powered healthcare products, highlighting gaps in safety evaluations, post-market surveillance, and ethical considerations. Artificial intelligence's continuous learning capabilities introduce unique risks, as algorithms evolve beyond their initial validation, potentially leading to performance degradation and biased outcomes. Although the U.S. Food and Drug Administration has taken steps to address these challenges, such as artificial intelligence/machine learning-based software as a medical device action plan and proposed regulatory adjustments, significant weaknesses remain, particularly in real-time monitoring, transparency and bias mitigation. This paper argues for a more adaptive, community-engaged regulatory approach that mandates extensive post-market evaluations, requires artificial intelligence developers to disclose training data sources, and establishes enforceable standards for fairness, equity, and accountability. A patient-centered regulatory framework must also integrate diverse perspectives to ensure artificial intelligence technologies serve all populations equitably. By fostering an agile, transparent, and ethics-driven oversight system, the U.S. Food and Drug Administration can balance innovation with patient safety, ensuring that artificial intelligence-driven medical technologies enhance, rather than compromise, healthcare outcomes.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.950
Threshold uncertainty score0.428

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.108
GPT teacher head0.439
Teacher spread0.330 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it