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Record W4413109314 · doi:10.1080/10669817.2025.2544285

Mechanosensitivity during straight leg raise and slump neurodynamic tests in people with type 1 diabetes mellitus and diabetic peripheral neuropathy

2025· article· en· W4413109314 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

aboutThe title or abstract carries a Canadian signal from the geographic lexicon.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueJournal of Manual & Manipulative Therapy · 2025
Typearticle
Languageen
FieldMedicine
TopicPeripheral Nerve Disorders
Canadian institutionsnot available
Fundersnot available
KeywordsMedicinePeripheral neuropathyDiabetes mellitusType 2 Diabetes MellitusDiabetic neuropathyPeripheralType 1 diabetesInternal medicineEndocrinology

Abstract

fetched live from OpenAlex

Objectives Neurodynamic tests are clinical tests used to identify heightened nerve mechanosensitivity but may be negative in the presence of severe neuropathy, as seen in people with carpal tunnel syndrome and type 2 diabetes. It is not known if this also occurs in people with diabetic peripheral neuropathy (DPN) from type 1 diabetes mellitus (T1DM). The primary aim of this study is to determine the proportion of positive neurodynamic tests in people with T1DM and DPN. The secondary aim is to assess whether the severity of DPN influences the presence of a positive neurodynamic test.Methods This is a cross-sectional study. Forty-three participants with T1DM and DPN were assessed using straight leg raise (SLR) and slump neurodynamic tests to determine a positive and negative test. DPN severity was graded according to Toronto Clinical Scoring System (TCSS).Results Forty-six percent and 56% of participants had positive SLR and slump tests, respectively, indicating heightened nerve mechanosensitivity. There was a statistically significant association between negative neurodynamic tests and DPN severity (p < 0.0001). In addition, participants with negative neurodynamic tests had significantly higher TCSS scores compared to participants with positive neurodynamic tests (p < 0.0001).Discussion/Conclusion People with T1DM and severe DPN, as graded by TCSS, are more likely to demonstrate negative neurodynamic tests than those with mild DPN. Future studies should investigate the relationship between neurodynamic tests and nerve function in other conditions. This supports previous research on negative neurodynamic tests in severe neuropathy, suggesting that neurodynamic tests should not be used alone to determine nerve involvement.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.300
Threshold uncertainty score0.876

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.273
Teacher spread0.261 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it