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Record W4414035743 · doi:10.1186/s42234-025-00183-8

Multi-system benefits of non-invasive spinal cord stimulation following cervical spinal cord injury: a case study

2025· article· en· W4414035743 on OpenAlexafffund
Soshi Samejima, Claire Shackleton, Raza N. Malik, Ali Hosseinzadeh, Lucas Rempel, Anh-Duong Phan, Alison M. M. Williams, Tom E. Nightingale, Amandeep Ghuman, Stacy Elliott, Matthias Walter, Klaus Krogh, Michael Berger, Tania Lam, Rahul Sachdeva, Andrei V. Krassioukov

Bibliographic record

VenueBioelectronic Medicine · 2025
Typearticle
Languageen
FieldMedicine
TopicSpinal Cord Injury Research
Canadian institutionsGF Strong Rehabilitation CentreSt. Paul's HospitalVancouver Coastal HealthInternational Collaboration On Repair DiscoveriesUniversity of British Columbia
FundersCanadian Institutes of Health ResearchWings for LifeInternational Spinal Research TrustFoundation for Physical TherapySchweizerische Multiple Sklerose GesellschaftInternational Foundation for Research in ParaplegiaWellcome TrustRick Hansen FoundationInternational Collaboration on Repair DiscoveriesCraig H. Neilsen FoundationParalyzed Veterans of AmericaU.S. Department of Defense
KeywordsSpinal cord injuryMedicineSpinal cordStimulationAnesthesiaInternal medicine

Abstract

fetched live from OpenAlex

Cervical spinal cord injury (SCI) impairs sensorimotor and autonomic functions. We investigated the effects of lumbosacral transcutaneous spinal cord stimulation (tSCS) on urinary bladder, bowel, and sexual function as well as cardiovascular and sensorimotor functions in one individual with chronic clinically motor-complete cervical SCI, 11 years post-injury. Following 30 sessions of lumbosacral tSCS, the individual presented with improved urinary bladder compliance as well as anorectal function in parallel with mitigation of the severity of autonomic dysreflexia during filling cystometry and anorectal manometry. In addition, long-term tSCS improved erectile function and sexual satisfaction. Furthermore, after long-term tSCS, concurrent tSCS enabled voluntary leg movement. This case study demonstrated the multi-system benefits of lumbosacral tSCS, which holds promise for evolving into a clinically viable therapy for restoring both autonomic and motor functions following SCI.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Case report · Consensus signal: Case report
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.008

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0020.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0030.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.077
GPT teacher head0.437
Teacher spread0.360 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designCase report
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations9
Published2025
Admission routes2
Has abstractyes

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