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Record W4414035743 · doi:10.1186/s42234-025-00183-8

Multi-system benefits of non-invasive spinal cord stimulation following cervical spinal cord injury: a case study

2025· article· en· W4414035743 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueBioelectronic Medicine · 2025
Typearticle
Languageen
FieldMedicine
TopicSpinal Cord Injury Research
Canadian institutionsGF Strong Rehabilitation CentreSt. Paul's HospitalVancouver Coastal HealthInternational Collaboration On Repair DiscoveriesUniversity of British Columbia
FundersCanadian Institutes of Health ResearchWings for LifeInternational Spinal Research TrustFoundation for Physical TherapySchweizerische Multiple Sklerose GesellschaftInternational Foundation for Research in ParaplegiaWellcome TrustRick Hansen FoundationInternational Collaboration on Repair DiscoveriesCraig H. Neilsen FoundationParalyzed Veterans of AmericaU.S. Department of Defense
KeywordsSpinal cord injuryMedicineSpinal cordStimulationAnesthesiaInternal medicine

Abstract

fetched live from OpenAlex

Cervical spinal cord injury (SCI) impairs sensorimotor and autonomic functions. We investigated the effects of lumbosacral transcutaneous spinal cord stimulation (tSCS) on urinary bladder, bowel, and sexual function as well as cardiovascular and sensorimotor functions in one individual with chronic clinically motor-complete cervical SCI, 11 years post-injury. Following 30 sessions of lumbosacral tSCS, the individual presented with improved urinary bladder compliance as well as anorectal function in parallel with mitigation of the severity of autonomic dysreflexia during filling cystometry and anorectal manometry. In addition, long-term tSCS improved erectile function and sexual satisfaction. Furthermore, after long-term tSCS, concurrent tSCS enabled voluntary leg movement. This case study demonstrated the multi-system benefits of lumbosacral tSCS, which holds promise for evolving into a clinically viable therapy for restoring both autonomic and motor functions following SCI.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Non-randomized trial · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.617
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.002
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.077
GPT teacher head0.437
Teacher spread0.360 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it