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Record W4414364879 · doi:10.1002/tcr.202500120

3D Printing‐Based Polymer Nanocomposites for Cancer Treatment: Innovations and Perspectives

2025· article· en· W4414364879 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueThe Chemical Record · 2025
Typearticle
Languageen
FieldEngineering
Topic3D Printing in Biomedical Research
Canadian institutionsUniversité du Québec à ChicoutimiUniversité du Québec à Trois-Rivières
FundersNational Taiwan University of Science and Technology
KeywordsBiocompatible materialNanocompositeCancer therapyPolymerFabricationMagnetic nanoparticlesPolymer nanocompositeDrug delivery

Abstract

fetched live from OpenAlex

Three-dimensional (3D) printing-based polymer nanocomposites have emerged as a transformative platform in cancer treatment due to their precision and ability to incorporate multifunctional features. These materials integrate biocompatible polymers with nanoscale components to create multifunctional structures that enhance drug delivery, tissue repair, and diagnostics. By incorporating nanoparticles, they enable localized treatment and improved visualization for real-time monitoring-offering a unified platform for therapy and diagnosis. By incorporating agents like liposomes, dendrimers, or magnetic nanocarriers, they achieve controlled release and tumor-specific action while minimizing systemic toxicity. In tissue engineering, these nanocomposites provide scaffolds that mimic the extracellular matrix, promoting cell adhesion, proliferation, and differentiation to repair tissues. Advanced 3D printing techniques ensure high-resolution fabrication of complex geometries tailored to individual patient needs. Polymer nanocomposites have shown significant potential in imaging applications, offering enhanced contrast in diagnostic techniques like magnetic resonance imaging, computed tomography, and fluorescence imaging. Functional nanoparticles, including quantum dots and gold nanostructures, are embedded into 3D-printed constructs to facilitate real-time tumor visualization. This multifunctionality allows the integration of therapy and diagnostics, paving the way for theranostic platforms. Furthermore, the scalability of 3D printing makes it suitable for precision medicine. Challenges remain in optimizing material properties, ensuring biocompatibility, and scaling production.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.287
Threshold uncertainty score0.266

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.027
GPT teacher head0.311
Teacher spread0.284 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it