Indoor allergens and endotoxins in relation to cockroach infestations in low-income urban homes
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Background: Cockroach allergens are well recognized as important risk factors in the development and prevalence of allergic rhinitis and asthma in children, especially in low-income urban households. The German cockroach gut hosts a diverse community of highly abundant microbes, including gram-negative bacteria that shed large amounts of endotoxins in cockroach feces. Objective: We sought to delineate the causal relationship between the presence of cockroaches in homes and levels of household endotoxins. Methods: In laboratory assays, we measured the amount of endotoxin produced by cockroaches. In-home monitoring estimated the size of the cockroach population in each home and quantified cockroach allergen Bla g 2 and endotoxin levels in household dust and on heating, ventilating, and air-conditioning (HVAC) filters. An environmental intervention was implemented in a subset of the infested homes to eliminate cockroaches. Bla g 2 and endotoxin levels were quantified for 6 months after the intervention. Results: Large amounts of endotoxin are excreted by female (2900 endotoxin units [EU]/mg feces) and male (1400 EU/mg) cockroaches. At baseline, household dust and HVAC filters in infested homes had significantly higher levels of allergen (Bla g 2) and endotoxin than uninfested homes. Environmental intervention resulted in significant declines in cockroaches as well as allergen and endotoxin levels. In contrast, cockroach numbers and allergen and endotoxin concentrations remained high in infested-control homes. Conclusions: Cockroaches are a significant source of both endotoxins and potent allergens, potentially resulting in coexposure of asthmatic children to both.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it