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Record W4414571703 · doi:10.1016/j.xops.2025.100949

Measuring Treatment Adherence in Myopia Control

2025· article· en· W4414571703 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueOphthalmology Science · 2025
Typearticle
Languageen
FieldMedicine
TopicOphthalmology and Visual Impairment Studies
Canadian institutionsUniversity of Waterloo
FundersFudan UniversityJohnson and Johnson Vision CareMetaAustralian Government
KeywordsControl (management)MEDLINEComponent (thermodynamics)Quality of life (healthcare)Quality (philosophy)

Abstract

fetched live from OpenAlex

Topic: Treatment adherence is an essential consideration for both health providers and researchers evaluating the effectiveness of treatments of progressive childhood myopia. This narrative review provides an overview of methods used to measure treatment adherence and examines how adherence has been assessed in myopia control studies. Clinical Relevance: Despite its importance, adherence has not been consistently measured or reported in myopia control trials, limiting the reliability of conclusions regarding treatment efficacy, dose relationships, and safety. Examining current approaches and highlighting methodological trends and gaps will inform future research. Methods: Exploratory searches of literature were undertaken to identify relevant studies conducted between 2014 and 2024. Studies were included if they met the following criteria: (1) reported on treatment adherence outcomes, (2) involved pediatric populations, and (3) evaluated a myopia control intervention. Reference lists of included articles were scanned to identify additional relevant studies. Results: In the context of research in myopia control interventions, direct measures of adherence are often impractical and largely dependent on the intervention being examined. This has led to inconsistent reporting of adherence outcomes across studies. Consequently, most studies to date have relied on indirect methods, particularly self-reported data, because of the limited availability of reliable electronic monitoring tools and the inaccuracy or inappropriateness of dosage counts. Conclusions: It is recommended that researchers prioritize treatment adherence as a key outcome and select context-appropriate methods that minimize bias and error. Optimal measurement of adherence outcomes will support more robust analyses of treatment dose-response relationships and ultimately inform the clinical care of myopic patients. Financial Disclosures: The authors have no proprietary or commercial interest in any materials discussed in this article.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.034
Threshold uncertainty score0.520

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.076
GPT teacher head0.393
Teacher spread0.317 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it