Sepsis neonatal dan faktor terkait pada bayi baru lahir : tinjauan sistematis dan meta-analisis
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Introduction: Neonatal sepsis remains a major cause of morbidity and mortality. Several studies have identified risk factors for neonatal sepsis, but these factors are limited to certain geographic regions and tend to show variable results between studies. Therefore, the purpose of this systematic review and meta-analysis was to determine the factors that contribute to the occurrence of neonatal sepsis in neonates. Methods: This meta-analysis used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A literature search was conducted using keywords through databases such as PubMed, Cochrane, ScienceDirect, and Cochrane. The study quality and bias assessment of included observational studies used the Newcastle-Ottawa quality assessment scale (NOS). The outcomes for risk factors for neonatal sepsis included: birth weight <2.5 kg, low APGAR score in the first minute, not crying after birth, delayed breastfeeding, urinary tract infection, and prolonged rupture of the membrane (PROM). RevMan 5.4 software was used for statistical analysis. Results: Literature search obtained 18 relevant full papers used in this meta-analysis study. The majority of studies used a case-control design with a total sample size of 6185 neonate samples. Factors associated with the occurrence of neonatal sepsis were birth weight <2.5 kg (OR: 1.91; 95 CI: 1.51-2.57; P <0.00001), low APGAR score in the first minute (OR: 3.09; 95 CI: 2.35-4.06; P <0.00001), late breastfeeding (OR: 3.41; 95 CI: 2.17-5.34; P <0.00001), urinary tract infection (OR: 4.04; 95 CI: 2.30-7.11; P <0.00001), and prolonged rupture of the membrane (PROM) (OR: 4.04; 95 CI: 2.30-7.11; P <0.00001). There was no association found between not crying after birth and neonatal sepsis (OR: 2.44; 95 CI: 0.74-8.05; P < 0.14). Conclusion: There was a significant association between birth weight <2.5 kg, low APGAR score in the first minute, delayed breastfeeding, urinary tract infection, and prolonged rupture of the membrane (PROM) with the occurrence of neonatal sepsis. Pendahuluan: Sepsis neonatal dilaporkan menjadi penyebab utama morbiditas dan mortalitas. Beberapa penelitian telah mengidentifikasi faktor risiko sepsis neonatal, tetapi faktor-faktor tersebut terbatas pada wilayah geografis tertentu dan cenderung menunjukkan hasil yang bervariasi antar studi. Oleh karena itu, tujuan tinjauan sistematis dan meta-analisis ini adalah menentukan faktor-faktor yang berkontribusi terhadap terjadinya sepsis neonatal pada neonatus. Metode: Meta-analisis ini menggunakan Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Pencarian literatur dilakukan menggunakan kata kunci melalui database seperti PubMed, Cochrane, ScienceDirect, dan Cochrane. Kualitas studi dan penilaian bias dari studi observasional yang disertakan menggunakan Newcastle-Ottawa quality assessment scale (NOS). Adapun outcome untuk faktor risiko sepsis neonatal, meliputi: berat badan < 2,5 kg, low APGAR score pada menit pertama, tidak menangis setelah lahir, breastfeeding yang terlambat, infeksi saluran kemih, dan prolonged rupture of the membrane (PROM). Perangkat lunak RevMan 5.4 digunakan untuk analisis statistik. Hasil: Penelusuran literatur memperoleh 18 full paper lengkap yang relevan digunakan pada studi meta-analisis ini. Mayoritas studi menggunakan desain case-control dengan jumlah total sampel adalah 6185 sampel neonatus. Faktor yang berhubungan dengan timbulnya sepsis neonatal adalah berat badan < 2,5 kg (OR: 1.91; 95 CI: 1.51-2.57; P < 0.00001), low APGAR score pada menit pertama (OR: 3.09; 95 CI: 2.35-4.06; P < 0.00001), breastfeeding yang terlambat (OR: 3.41; 95 CI: 2.17-5.34; P < 0.00001), infeksi saluran kemih (OR: 4.04; 95 CI: 2.30-7.11; P < 0.00001), dan prolonged rupture of the membrane (PROM) (OR: 4.04; 95 CI: 2.30-7.11; P < 0.00001). Tidak ditemukan adanya hubungan antara tidak menangis setelah lahir dengan sepsis neonatal (OR: 2,44; 95 CI: 0.74-8.05; P < 0.14). Kesimpulan: Adanya hubungan yang bermakna antara berat badan < 2,5 kg, low APGAR score pada menit pertama, breastfeeding yang terlambat, infeksi saluran kemih, dan prolonged rupture of the membrane (PROM) dengan timbulnya sepsis neonatal.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.013 | 0.025 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.003 |
| Insufficient payload (model declined to judge) | 0.012 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it