Emerging Roles of GluN3B NMDA Receptor Subunit in the Central Nervous System
Bibliographic record
Abstract
GluN3B is the most recently identified subunit of N-methyl-d-aspartate receptors (NMDARs), and gradually it has been found that it may be involved in regulating the development of central nervous system (CNS)-related diseases. Compared with the traditional NMDARs containing only GluN1 and GluN2 subunits, non-classical NMDARs with GluN3 have non-conventional biophysical, trafficking, and signaling properties. As a negative regulatory subunit that diminishes or inhibits classical NMDARs' functions, GluN3B plays important roles in synaptic plasticity and neuronal survival, and may be associated with CNS disorders such as schizophrenia and substance use disorders. However, the number and depth of studies on how GluN3B is involved in the regulation of related diseases are very limited. This review summarizes the expression and physiological characterization of GluN3B-NMDARs and provides an overview of their emerging roles in psychiatric and neuropsychiatric disorders, aiming to provide a basis for understanding disease mechanisms and developing novel therapeutic targets.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".