Thermoregulation during exercise under controlled hot ambient conditions is comparable in individuals with a history of exertional heat stroke, <i>RYR1</i> -related malignant hyperthermia, and healthy controls
Why this work is in the frame
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Bibliographic record
Abstract
Exertional heat stroke (EHS) and Malignant Hyperthermia (MH) are potentially life-threatening conditions with overlapping clinical characteristics. In this study, we compared the thermoregulatory response to exercise under increased environmental temperatures in individuals with a history of EHS (n = 15) or MH (n = 14) to healthy controls (n = 15). Groups were age- and sex-matched (31 male, 13 female, 42 ± 10 years). A 60-min exercise test was performed on a cycle ergometer at an ambient temperature of 30.3 ± 0.6°C and a relative humidity of 33.5 ± 4.7%. A stepwise incremental exercise protocol was used to reach a metabolic heat production of 6, 8 and 9 W/kg body mass. Gastrointestinal (Tgi) and skin (Tsk) temperature were monitored continuously, and partitional calorimetry was used to calculate dry (Hdry) and respiratory heat loss (Hresp). Whole-body sweat rate (WBSR) was assessed by measuring body mass. Exercise-induced increases in Tgi (1.4 ± 0.5°C) and Tsk (1.9 ± 0.8°C) were observed, but the magnitude of increase across groups was comparable (ptime*group = 0.80 and p = 0.57, respectively). Hdry was significantly lower in EHS participants (54 ± 4 W) compared to controls (65 ± 11 W, p = 0.023). No differences were observed in Hresp and WBSR. Our results suggest that individuals with MH or a history of EHS do not have an altered thermoregulatory response to exercise in the heat in a controlled setting. Further research is required to determine to what extent the complex accumulation of risk factors contributes to EHS susceptibility.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it