Double-Blind Randomized Placebo-Controlled Trial of a Lactobacillus Probiotic Blend in Chronic Obstructive Pulmonary Disease
Why this work is in the frame
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Bibliographic record
Abstract
Gut microbiota modulate systemic anti-inflammatory and immune responses in the lungs, suggesting a potential to support lung health through probiotic supplementation. We hypothesized that a probiotic blend (Lactobacilli) combined with herbal extracts (resB®) could improve quality of life in patients with chronic obstructive pulmonary disease (COPD). We conducted a randomized, double-blinded, placebo-controlled study (NCT05523180) evaluating the safety and impact of resB® on quality of life in volunteers with COPD. Participants took resB® or placebo (two capsules daily) for 12 weeks. The primary endpoint was change in quality of life by Saint George’s Respiratory Questionnaire (SGRQ). Secondary outcomes included safety, serum and sputum biomarkers, and microbiome analysis. resB® was well tolerated with no related adverse events. Participants receiving resB® showed significant improvement in SGRQ symptom scores (P < 0.05), while placebo recipients did not. In the resB® group, serum and sputum levels of matrix metalloproteinase 9, C-reactive protein, and interleukin 6 decreased (P < 0.05), correlating with increased stool Lactobacilli. Additionally, Veillonella abundance increased in both stool and sputum. These findings suggest that resB® improves respiratory symptoms and reduces inflammation in patients with COPD, potentially by modulating gut and lung microbiota. ClinicalTrials.gov identifier NCT05523180. Chronic obstructive pulmonary disease (COPD) is a long-term lung condition that makes breathing difficult and greatly affects quality of life. Current treatments mostly focus on reducing symptoms, but there is a need for safe supportive approaches. The gut and the lungs communicate through what is known as the “gut–lung axis.” Changes in gut bacteria can influence inflammation and immunity in the lungs. Probiotics (beneficial bacteria) and plant-based extracts may help improve this communication and support lung health. In this study, adults with COPD were randomly assigned to receive either a probiotic and herbal blend (resB®) or a placebo for 12 weeks. Participants and researchers did not know which treatment each person received until the study ended. The main outcome was change in quality of life, measured by the Saint George’s Respiratory Questionnaire (SGRQ). We also looked at safety, inflammation in the blood and sputum, and changes in gut and lung bacteria. We found that resB® was safe and well tolerated. People who took resB® showed improvement in COPD-related symptoms compared to those who received placebo. Inflammatory markers in the blood and sputum decreased, and certain beneficial bacteria became more abundant in the gut and lungs. These results suggest that resB® may support people with COPD by improving symptoms and reducing inflammation. More research in larger studies is needed to confirm these findings and better understand how probiotics and plant extracts work through the gut–lung axis.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it