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Record W4416443317 · doi:10.5376/be.2025.15.0023

Genetic Approaches to Minimize Gluten in Wheat

2025· article· W4416443317 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

venuePublished in a venue whose home country is Canada.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueBiological Evidence · 2025
Typearticle
Language
FieldAgricultural and Biological Sciences
TopicWheat and Barley Genetics and Pathology
Canadian institutionsnot available
Fundersnot available
KeywordsGlutenRNA interferenceMutagenesisTILLINGGeneStaple foodGluten freeGenome editingImmune system

Abstract

fetched live from OpenAlex

The gluten in wheat is the key to making staple foods like bread taste good. But it is also the main cause of celiac disease and some gluten intolerance diseases. Nowadays, there are many ways to reduce gluten, such as RNA interference, gene editing, mutagenesis screening and molecular marker breeding. Gene editing technologies like CRISPR/Cas9 can precisely knock out or modify multiple copies of the alcohol-soluble protein gene. This can significantly reduce the immune response while still retaining the processing performance of the dough. Researchers have obtained low-gluten wheat strains without genetically modified residues. Methods such as RNAi and TILLING can also lower the level of low-gluten protein and improve the nutritional components of wheat. These improvement measures not only offer celiac disease patients safer choices of staple foods, but also drive the development of healthy foods. In the future, if multi-omics analysis, personalized breeding and synthetic biology can be combined, it is possible to cultivate a new generation of low-gluten wheat that is both safe and delicious. This is precisely the goal of our research.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.460
Threshold uncertainty score0.791

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.243
GPT teacher head0.282
Teacher spread0.039 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it