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Record W4416443317 · doi:10.5376/be.2025.15.0023

Genetic Approaches to Minimize Gluten in Wheat

2025· article· W4416443317 on OpenAlexvenueno aff
Wei Wang

Bibliographic record

VenueBiological Evidence · 2025
Typearticle
Language
FieldAgricultural and Biological Sciences
TopicWheat and Barley Genetics and Pathology
Canadian institutionsnot available
Fundersnot available
KeywordsGlutenRNA interferenceMutagenesisTILLINGGeneStaple foodGluten freeGenome editingImmune system

Abstract

fetched live from OpenAlex

The gluten in wheat is the key to making staple foods like bread taste good. But it is also the main cause of celiac disease and some gluten intolerance diseases. Nowadays, there are many ways to reduce gluten, such as RNA interference, gene editing, mutagenesis screening and molecular marker breeding. Gene editing technologies like CRISPR/Cas9 can precisely knock out or modify multiple copies of the alcohol-soluble protein gene. This can significantly reduce the immune response while still retaining the processing performance of the dough. Researchers have obtained low-gluten wheat strains without genetically modified residues. Methods such as RNAi and TILLING can also lower the level of low-gluten protein and improve the nutritional components of wheat. These improvement measures not only offer celiac disease patients safer choices of staple foods, but also drive the development of healthy foods. In the future, if multi-omics analysis, personalized breeding and synthetic biology can be combined, it is possible to cultivate a new generation of low-gluten wheat that is both safe and delicious. This is precisely the goal of our research.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0010.000
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.243
GPT teacher head0.282
Teacher spread0.039 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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