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Record W4416756483 · doi:10.1038/s41526-025-00536-2

Sensory network segregation as a predictor of post spaceflight balance impairments and sensory re-weighting

2025· article· en· W4416756483 on OpenAlexfundno aff
GD Tays, TD Fettrow, Heather R. McGregor, Kathleen E. Hupfeld, YE De Dios, PA Reuter-Lorenz, JJ Bloomberg, A. P. Mulavara, SJ Wood, Rachael D. Seidler

Bibliographic record

Venuenpj Microgravity · 2025
Typearticle
Languageen
FieldMedicine
TopicSpaceflight effects on biology
Canadian institutionsnot available
FundersNatural Sciences and Engineering Research Council of CanadaNational Institute on AgingNational Institutes of HealthNuclear Safety and Security CommissionNational Aeronautics and Space Administration
KeywordsSensory systemBalance (ability)Vestibular systemSpaceflightSomatosensory systemWeighting

Abstract

fetched live from OpenAlex

Exposure to microgravity results in transient sensorimotor performance declines when crewmembers return to Earth, likely due to sensory re-weighting. This poses performance risks following gravitational transitions, such as arriving on the Moon or Mars. Here, we examined whether sensory brain network segregation (how independently a given network functions) in astronauts prior to an International Space Station mission would predict balance post-flight. Intraclass correlation analysis showed high test-retest reliability for all sensory network segregation measures. Indices of the Parietal Operculum 2 network (OP2) segregation pre-flight significantly predicted balance performance. Specifically, greater segregation predicted poorer balance on day one following return to Earth (Left OP2), better balance four days post-flight (Left and Right OP2) and greater balance improvements from one to four days post-flight. Results suggest that OP2 segregation may index plasticity of sensory weighting processes; that is, the degree of vestibular input down-weighting measured initially post-flight and extent of recovery over subsequent four days.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.276
Teacher spread0.269 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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