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Record W4416880045 · doi:10.54195/9789465151793

Serotonin in the Bayesian brain

2025· book· W4416880045 on OpenAlexfundno aff
Filip Novický

Bibliographic record

VenueRadboud University Press eBooks · 2025
Typebook
Language
FieldPsychology
TopicPsychedelics and Drug Studies
Canadian institutionsnot available
FundersHORIZON EUROPE Marie Sklodowska-Curie ActionsTechnische Universiteit DelftMedical Research CouncilMedical Research Council CanadaDeutsche ForschungsgemeinschaftEuropean Commission
KeywordsSensory systemBayesian probabilityArtificial neural networkPerceptionSerotonergicBayesian inferenceMechanism (biology)Inference

Abstract

fetched live from OpenAlex

While theoretical models increasingly use Bayesian frameworks to explain neural processing, a significant gap exists in understanding how these mathematical principles are biologically implemented. This thesis proposes that serotonin serves as a biological mechanism for precision modulation in predictive processing, tested through experiments on exploratory behavior, perceptual illusions, and psychedelic-induced neural states. The research reveals how serotonergic modulation in rodent whisking behavior demonstrates precision weighting as a key mechanism influencing sensory processing. Using active inference frameworks, the work shows serotonin modulates the precision of sensory inputs and prior habits, regulating exploratory behavior and environmental sampling. Robotics experiments translate these biological insights into artificial systems, demonstrating how precision-based active inference can guide autonomous behavior in humanoid robots through adaptive sensorimotor control and efficient information seeking. Theoretical work on attention and body ownership illusions explores precision control in embodied systems. Mathematical modeling of the rubber hand illusion shows how the brain arbitrates between competing sensory models via precision-weighted inference. Analysis of psilocybin's neural effects demonstrates that this serotonergic agent increases chaotic brain responses and neural transition complexity, supporting theories that psychedelics decrease hierarchical neural communication precision through fundamental reorganization of neural dynamics.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.004
Threshold uncertainty score0.015

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.003
Scholarly communication0.0010.002
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.030
GPT teacher head0.280
Teacher spread0.250 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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