Data for the manuscript: Fecal Transplant Prevents Gut Dysbiosis and Anxiety-like Behaviour After Spinal Cord Injury in Rats
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
STUDY PURPOSE: To establish a model of anxiety following a cervical contusion spinal cord injury (SCI) in rats and to determine whether the microbiota play a role in the observed behavioural changes. DATA COLLECTED: This dataset includes n=57 rats from 2 experiments. Experiment 1: sham (underwent surgery with no SCI) n=6; unilateral cervical contusion SCI n=6. Experiment 2: Healthy (no operation, no gavage) n=10; Sham n=11; SCI (gavaged with a control solution) n=10; SCI-FMT (gavaged with fecal microbiota transplant solution) n=14. A subset of subjects from experiment 2 were used for the fecal 16s rRNA analysis (healthy n = 10; SCI-FMT n = 10; sham n = 5; SCI n = 5). Fecal matter for the 16s rRNA analysis were collected before injury, 3 days after injury and 4 weeks after injury. A PICRUST analysis was performed to infer the functional pathways involved using the 16s rRNA gene data. Rats were assessed on a battery of behavioural tests: the light-dark box, the cylinder test, the sucrose preference test, the elevated plus maze and the open field. Lesion size was calculated as the percentage of damaged tissue area throughout the rostral-caudal extension of the injury site. PRIMARY CONCLUSION: Treatment with a fecal microbiota transplant in the acute post-injury period prevents spinal cord injury-induced gut dysbiosis as well as the development of anxiety-like behaviour.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.003 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it