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Record W7019419271

The genetic control of airway responsiveness and the effect of resiquimod treatment on allergic asthma

2010· dissertation· en· W7019419271 on OpenAlexfundno aff

Bibliographic record

VenueeScholarship@McGill (McGill) · 2010
Typedissertation
Languageen
FieldSocial Sciences
TopicGenerational Differences and Trends
Canadian institutionsnot available
FundersNatural Sciences and Engineering Research Council of CanadaCanadian Institutes of Health ResearchAmerican Asthma Foundation
KeywordsOvalbuminImmune systemAsthmaReceptorAirwayCytokineImmunoglobulin EAirway hyperresponsiveness
DOInot available

Abstract

fetched live from OpenAlex

A disintegrin and metalloprotease 33 AHR Airway hyperresponsiveness AR Airway responsiveness ASM Airway smooth muscle B C57BL/6 BAL Bronchoalveolar lavage BALF BAL fluid BCG Bacillus Calmette-Guérin CAMS cell adhesion molecules CCAC Canadian council on animal care Ccl chemokine (C-C motif) ligand CIHR Canadian institutes of health research CpG Unmethylated CG DNA CR Congo red CXCL chemokine (C-X-C motif) ligand DPP10 Dipeptidyl-peptidase 10 DSO Donor strain of origin EAE Experimental autoimmune encephalitis ECM Extracellular matrix Ers Respiratory system elastance FcεR Fc receptor, IgE Foxp3 Forkhead box P3 GAPDH Glyceraldehyde-3-phosphate dehydrogenase GPRA G protein-coupled receptor for asthma susceptibility GXD Gene expression database H&E Haematoxylin and eosin HCV Hepatitis C virus HPV Human papillomavirus IBD Identical by descent ICS Inhaled corticosteroids IDO Indoleamine 2,3-dioxygenase IFN Interferon Ig Immunoglobulin IL Interleukin Klr Killer cell lectin-like receptor contributed to experimental design, some sample manipulations, and/or editing of the manuscript.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.002

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.263
Teacher spread0.253 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2010
Admission routes1
Has abstractyes

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