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Record W7126232837 · doi:10.1162/nol.e.241

The White Matter Connectome Supporting Speech and Language in the Human

2025· article· en· W7126232837 on OpenAlexaff
Anthony Steven Dick, Pascale Tremblay

Bibliographic record

VenueNeurobiology of Language · 2025
Typearticle
Languageen
FieldMedicine
TopicAdvanced Neuroimaging Techniques and Applications
Canadian institutionsUniversité Laval
Fundersnot available
KeywordsWhite matterConnectomeConnectomicsLateralization of brain functionDiffusion MRIReading (process)Functional connectivityHuman brain

Abstract

fetched live from OpenAlex

The neurobiology of language has moved beyond the classical dorsal-ventral dichotomy to embrace a more complex, distributed, and dynamic white matter connectome. This special issue, The White Matter Connectome Supporting Speech and Language in the Human, presents 10 empirical studies that leverage traditional and advanced diffusion modeling and analyses-including Restriction Spectrum Imaging, fixel-based analysis, and network control theory-to map this complexity. The contributions are organized into three themes: developmental plasticity, lateralization, and clinical resilience. Findings range from the rapid consolidation of speech categories during sleep and the microstructural scaffolding of early childhood speech, to the surprising stability of reading networks following educational disruption. Novel insights into lateralization challenge binary left-right models, revealing how interhemispheric balance and intrahemispheric asymmetry jointly shape functional dominance. Finally, clinical studies on aphasia, dyslexia, and stroke recovery demonstrate how structural connectivity constrains therapeutic outcomes, identifying specific white matter targets for semantic versus phonological recovery. Collectively, these articles advance a framework where the white matter connectome is not merely a static system, but an active, plastic substrate essential for human communication.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.010

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0020.001
Science and technology studies0.0000.001
Scholarly communication0.0010.002
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.366
Teacher spread0.344 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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