The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability
2007· article· en· Nature Protocols· Biochemistry, Genetics and Molecular Biology
affno abstract
2,442
citations
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Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family
2012· article· en· Cell· Biochemistry, Genetics and Molecular Biology
afffund
1,752
citations
Epigenetic protein families: a new frontier for drug discovery
2012· review· en· Nature Reviews Drug Discovery· Biochemistry, Genetics and Molecular Biology
afffundno abstract
1,308
citations
Targeted protein degradation: expanding the toolbox
2019· review· en· Nature Reviews Drug Discovery· Biochemistry, Genetics and Molecular Biology
affno abstract
938
citations
An international perspective on Tourette syndrome: selected findings from 3500 individuals in 22 countries
2000· article· en· Developmental Medicine & Child Neurology· Psychology
aff
867
citations
Consistent blind protein structure generation from NMR chemical shift data
2008· article· en· Proceedings of the National Academy of Sciences· Biochemistry, Genetics and Molecular Biology
aff
864
citations
The promise and peril of chemical probes
2015· article· en· Nature Chemical Biology· Chemistry
afffund
850
citations
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
2012· article· en· Nature Chemical Biology· Biochemistry, Genetics and Molecular Biology
afffundno abstract
825
citations
Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids
2015· article· en· Nature Medicine· Medicine
affno abstract
749
citations
Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain
2014· article· en· Nature Chemical Biology· Biochemistry, Genetics and Molecular Biology
afffundno abstract
708
citations
Structure and function of WD40 domain proteins
2011· review· en· Protein & Cell· Biochemistry, Genetics and Molecular Biology
afffund
658
citations
645
citations
607
citations
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
2006· article· en· Proceedings of the National Academy of Sciences· Materials Science
afffund
594
citations
A systematic analysis of atomic protein–ligand interactions in the PDB
2017· article· en· MedChemComm· Computer Science
afffund
593
citations
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017· article· en· Science· Biochemistry, Genetics and Molecular Biology
afffund
559
citations
Self-renewal as a therapeutic target in human colorectal cancer
2013· article· en· Nature Medicine· Medicine
afffundno abstract
534
citations
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
2011· article· en· Nature Chemical Biology· Biochemistry, Genetics and Molecular Biology
afffundno abstract
531
citations
Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth
2015· article· en· Nature· Biochemistry, Genetics and Molecular Biology
affno abstract
489
citations
Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1
2008· article· en· Nature· Biochemistry, Genetics and Molecular Biology
affno abstract
469
citations
An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1
2013· article· en· ACS Chemical Biology· Biochemistry, Genetics and Molecular Biology
aff
466
citations
Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
2012· article· en· Nature Biotechnology· Medicine
afffundno abstract
460
citations
A clinically applicable integrative molecular classification of meningiomas
2021· article· en· Nature· Medicine
affno abstract
456
citations
Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy
2017· article· en· Nature· Biochemistry, Genetics and Molecular Biology
afffundno abstract
418
citations
Protein arginine methylation: from enigmatic functions to therapeutic targeting
2021· review· en· Nature Reviews Drug Discovery· Biochemistry, Genetics and Molecular Biology
affno abstract
415
citations