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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.
Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Opus teacher head0.006
GPT teacher head0.254
- Teacher spread
- 0.248 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
The record
- Venue
- Nature Chemical Biology
- Topic
- Cancer, Hypoxia, and Metabolism
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- Structural Genomics ConsortiumUniversity of Toronto
- Funders
- Argonne National LaboratoryBiological and Environmental ResearchNational Institute of General Medical SciencesNational Institute of Mental HealthNational Cancer InstituteNational Institutes of HealthKnut och Alice Wallenbergs StiftelseWellcome TrustCanadian Institutes of Health ResearchGenome CanadaUniversity of ChicagoHoward Hughes Medical Institute
- Keywords
- PKM2Pyruvate kinaseBiochemistryGlycolysisCell growthTyrosine kinaseKinaseBiologyPyruvate dehydrogenase kinaseChemistryCell biologyEnzymePyruvate dehydrogenase complexSignal transduction
- Has abstract in OpenAlex
- no