Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
2000· article· en· Nature· Medicine
affno abstract
1,431
citations
Works
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654 workspage 1 of 27
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
2007· article· en· Nature Genetics· Medicine
affno abstract
1,169
citations
Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695
2001· article· en· Journal of Biological Chemistry· Medicine
aff
954
citations
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing
2000· article· en· Nature· Biochemistry, Genetics and Molecular Biology
affno abstract
904
citations
Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future
2023· review· en· Signal Transduction and Targeted Therapy· Medicine
aff
887
citations
Green Tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice
2005· article· en· Journal of Neuroscience· Medicine
fundno aff
707
citations
The β-Secretase BACE1 in Alzheimer’s Disease
2020· review· en· Biological Psychiatry· Medicine
affno abstract
666
citations
Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression
2006· article· en· Proceedings of the National Academy of Sciences· Medicine
afffund
601
citations
γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?
2002· review· en· Nature reviews. Neuroscience· Medicine
afffundno abstract
509
citations
Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes
2012· article· en· Journal of Clinical Investigation· Medicine
afffund
435
citations
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
2010· article· en· Brain· Medicine
aff
429
citations
Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease
2011· article· en· The International Journal of Neuropsychopharmacology· Medicine
afffund
424
citations
Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis
2008· article· en· Neuron· Biochemistry, Genetics and Molecular Biology
fundno affno abstract
418
citations
Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1
2000· article· en· Nature Cell Biology· Medicine
affno abstract
409
citations
Cargo proteins of plasma astrocyte‐derived exosomes in Alzheimer's disease
2016· article· en· The FASEB Journal· Medicine
fundno aff
408
citations
Neprilysin Gene Transfer Reduces Human Amyloid Pathology in Transgenic Mice
2003· article· en· Journal of Neuroscience· Neuroscience
fundno aff
387
citations
Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver
2012· article· en· Proceedings of the National Academy of Sciences· Medicine
afffund
383
citations
Binding of the Positron Emission Tomography Tracer Pittsburgh Compound-B Reflects the Amount of Amyloid-β in Alzheimer's Disease Brain But Not in Transgenic Mouse Brain
2005· article· en· Journal of Neuroscience· Medicine
aff
376
citations
Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models
2008· article· en· The Journal of Experimental Medicine· Medicine
afffund
365
citations
Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease
2013· article· en· Neuropharmacology· Medicine
fundno affno abstract
353
citations
Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease.
2004· review· en· PubMed· Medicine
aff
349
citations
Absence of C1q Leads to Less Neuropathology in Transgenic Mouse Models of Alzheimer's Disease
2004· article· en· Journal of Neuroscience· Medicine
fundno aff
348
citations
Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP
2005· article· en· Neuron· Medicine
affno abstract
334
citations
A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ
2019· article· en· Neuron· Medicine
fundno affno abstract
332
citations
328
citations