CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes
2007· article· en· Science· Environmental Science
aff
6,292
citations
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An updated evolutionary classification of CRISPR–Cas systems
2015· review· en· Nature Reviews Microbiology· Biochemistry, Genetics and Molecular Biology
affno abstract
2,570
citations
Evolution and classification of the CRISPR–Cas systems
2011· review· en· Nature Reviews Microbiology· Biochemistry, Genetics and Molecular Biology
affno abstract
2,496
citations
Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants
2019· review· en· Nature Reviews Microbiology· Biochemistry, Genetics and Molecular Biology
affno abstract
2,464
citations
The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
2010· article· en· Nature· Biochemistry, Genetics and Molecular Biology
afffundno abstract
2,344
citations
CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia
2020· article· en· New England Journal of Medicine· Medicine
afffund
1,856
citations
High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
2015· article· en· Cell· Biochemistry, Genetics and Molecular Biology
afffundno abstract
1,790
citations
Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components
2016· article· en· Cell· Medicine
affno abstract
1,477
citations
Phage Response to CRISPR-Encoded Resistance in Streptococcus thermophilus
2007· article· en· Journal of Bacteriology· Environmental Science
afffund
1,245
citations
Transgenic Mice for Intersectional Targeting of Neural Sensors and Effectors with High Specificity and Performance
2015· article· en· Neuron· Neuroscience
affno abstract
1,228
citations
Lipid Nanoparticle Systems for Enabling Gene Therapies
2017· review· en· Molecular Therapy· Biochemistry, Genetics and Molecular Biology
afffundabout
1,120
citations
Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination
2013· article· en· Nature Methods· Biochemistry, Genetics and Molecular Biology
fundno affno abstract
1,066
citations
Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs
2014· article· en· PLoS ONE· Biochemistry, Genetics and Molecular Biology
aff
996
citations
Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system
2012· article· en· Nature· Biochemistry, Genetics and Molecular Biology
afffundno abstract
861
citations
Applications of CRISPR–Cas in agriculture and plant biotechnology
2020· review· en· Nature Reviews Molecular Cell Biology· Biochemistry, Genetics and Molecular Biology
affno abstract
835
citations
Diversity, Activity, and Evolution of CRISPR Loci in Streptococcus thermophilus
2007· article· en· Journal of Bacteriology· Biochemistry, Genetics and Molecular Biology
afffund
795
citations
A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria
2016· article· en· Cell· Biochemistry, Genetics and Molecular Biology
affno abstract
786
citations
Qualitative research methodologies: ethnography
2008· article· en· BMJ· Biochemistry, Genetics and Molecular Biology
aff
776
citations
Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids
2015· article· en· Nature Communications· Biochemistry, Genetics and Molecular Biology
afffund
774
citations
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
2021· article· en· Nature· Biochemistry, Genetics and Molecular Biology
affno abstract
768
citations
Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing
2019· article· en· Nature Biotechnology· Biochemistry, Genetics and Molecular Biology
affno abstract
724
citations
Revenge of the phages: defeating bacterial defences
2013· review· en· Nature Reviews Microbiology· Environmental Science
afffundno abstract
713
citations
Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens
2017· article· en· G3 Genes Genomes Genetics· Biochemistry, Genetics and Molecular Biology
afffundabout
681
citations
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
2015· article· en· Nature Biotechnology· Biochemistry, Genetics and Molecular Biology
fundno affno abstract
630
citations
CRISPR/Cas System and Its Role in Phage-Bacteria Interactions
2010· review· en· Annual Review of Microbiology· Biochemistry, Genetics and Molecular Biology
aff
620
citations