CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia
2020· article· en· New England Journal of Medicine· Medicine
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1,856
citations
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Lipid Nanoparticle Systems for Enabling Gene Therapies
2017· review· en· Molecular Therapy· Biochemistry, Genetics and Molecular Biology
afffundabout
1,120
citations
Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination
2013· article· en· Nature Methods· Biochemistry, Genetics and Molecular Biology
fundno affno abstract
1,066
citations
Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs
2014· article· en· PLoS ONE· Biochemistry, Genetics and Molecular Biology
aff
996
citations
Prime genome editing in rice and wheat
2020· article· en· Nature Biotechnology· Biochemistry, Genetics and Molecular Biology
affno abstract
869
citations
Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system
2012· article· en· Nature· Biochemistry, Genetics and Molecular Biology
afffundno abstract
861
citations
Applications of CRISPR–Cas in agriculture and plant biotechnology
2020· review· en· Nature Reviews Molecular Cell Biology· Biochemistry, Genetics and Molecular Biology
affno abstract
835
citations
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
2021· article· en· Nature· Biochemistry, Genetics and Molecular Biology
affno abstract
768
citations
Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing
2019· article· en· Nature Biotechnology· Biochemistry, Genetics and Molecular Biology
affno abstract
724
citations
Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens
2017· article· en· G3 Genes Genomes Genetics· Biochemistry, Genetics and Molecular Biology
afffundabout
681
citations
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
2015· article· en· Nature Biotechnology· Biochemistry, Genetics and Molecular Biology
fundno affno abstract
630
citations
CRISPR/Cas System and Its Role in Phage-Bacteria Interactions
2010· review· en· Annual Review of Microbiology· Biochemistry, Genetics and Molecular Biology
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620
citations
Precision-engineering the Pseudomonas aeruginosa genome with two-step allelic exchange
2015· article· en· Nature Protocols· Biochemistry, Genetics and Molecular Biology
afffundno abstract
609
citations
High-content CRISPR screening
2022· article· en· Nature Reviews Methods Primers· Biochemistry, Genetics and Molecular Biology
affno abstract
574
citations
CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs
2016· article· en· Cell stem cell· Biochemistry, Genetics and Molecular Biology
fundno affno abstract
549
citations
Expanded base editing in rice and wheat using a Cas9-adenosine deaminase fusion
2018· article· en· Genome biology· Biochemistry, Genetics and Molecular Biology
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496
citations
Applications and potential of genome editing in crop improvement
2018· review· en· Genome biology· Biochemistry, Genetics and Molecular Biology
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427
citations
Anti-CRISPR: discovery, mechanism and function
2017· review· en· Nature Reviews Microbiology· Biochemistry, Genetics and Molecular Biology
affno abstract
409
citations
The CRISPR-Cas toolbox and gene editing technologies
2021· review· en· Molecular Cell· Biochemistry, Genetics and Molecular Biology
affno abstract
397
citations
Lipid nanoparticle technology for therapeutic gene regulation in the liver
2020· review· en· Advanced Drug Delivery Reviews· Biochemistry, Genetics and Molecular Biology
afffundno abstract
362
citations
Cas9 gRNA engineering for genome editing, activation and repression
2015· article· en· Nature Methods· Biochemistry, Genetics and Molecular Biology
fundno affno abstract
356
citations
Efficient generation of targeted large insertions by microinjection into two-cell-stage mouse embryos
2018· article· en· Nature Biotechnology· Biochemistry, Genetics and Molecular Biology
affno abstract
347
citations
Generation of herbicide tolerance traits and a new selectable marker in wheat using base editing
2019· letter· en· Nature Plants· Biochemistry, Genetics and Molecular Biology
affno abstract
345
citations
An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells
2020· article· en· Cell· Biochemistry, Genetics and Molecular Biology
fundno affno abstract
342
citations
A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ
2019· article· en· Neuron· Medicine
fundno affno abstract
332
citations