CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.236 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
The record
- Venue
- Cell stem cell
- Topic
- CRISPR and Genetic Engineering
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- —
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institute of Biomedical Imaging and BioengineeringHoward Hughes Medical InstituteNational Institute of Allergy and Infectious DiseasesNational Institute of General Medical SciencesNational Institutes of HealthCanadian Institutes of Health ResearchInnovative Genomics InstituteUniversity of California, San FranciscoCenter for AIDS Research, University of WashingtonNational Heart, Lung, and Blood InstituteGladstone InstitutesNational Institute on Drug Abuse
- Keywords
- BiologyCRISPRCRISPR interferenceInduced pluripotent stem cellGene silencingCas9Genome editingRNA interferencePsychological repressionRegulation of gene expressionGene expressionGeneCell biologyGene knockdownGeneticsComputational biologyTranscription activator-like effector nucleaseEmbryonic stem cellRNA
- Has abstract in OpenAlex
- no