Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction
2023· review· en· Cell Death and Disease· Medicine
fundno aff
739
citations
Works
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212 workspage 1 of 9
α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study
2011· article· en· The Lancet Neurology· Medicine
affno abstract
629
citations
Alpha‐synuclein <scp>RT</scp>‐Qu<scp>IC</scp> in the <scp>CSF</scp> of patients with alpha‐synucleinopathies
2016· article· en· Annals of Clinical and Translational Neurology· Medicine
fundno aff
613
citations
α-Synuclein Membrane Interactions and Lipid Specificity
2000· article· en· Journal of Biological Chemistry· Medicine
afffund
608
citations
REM sleep behaviour disorder
2018· review· en· Nature Reviews Disease Primers· Neuroscience
affno abstract
487
citations
Induction of α-Synuclein Aggregation by Intracellular Nitrative Insult
2001· article· en· Journal of Neuroscience· Medicine
fundno aff
442
citations
Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?
2016· review· en· Journal of Parkinson s Disease· Medicine
afffund
425
citations
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction
2018· article· en· Nature Communications· Medicine
aff
335
citations
Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study
2021· article· en· The Lancet Neurology· Medicine
fundno affno abstract
332
citations
α-Synuclein strains target distinct brain regions and cell types
2019· article· en· Nature Neuroscience· Biochemistry, Genetics and Molecular Biology
affno abstract
329
citations
CNS expression of glucocerebrosidase corrects α-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy
2011· article· en· Proceedings of the National Academy of Sciences· Medicine
aff
317
citations
Interface between tauopathies and synucleinopathies: A tale of two proteins
2006· review· en· Annals of Neurology· Medicine
aff
264
citations
Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder
2021· review· en· The Lancet Neurology· Medicine
affno abstract
242
citations
Imaging biomarkers in Parkinson’s disease and Parkinsonian syndromes: current and emerging concepts
2017· review· en· Translational Neurodegeneration· Medicine
afffund
235
citations
α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia
2006· article· en· Neurobiology of Aging· Medicine
affno abstract
230
citations
Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies
2021· article· en· Brain· Medicine
afffund
190
citations
Executive dysfunction and memory impairment in idiopathic REM sleep behavior disorder
2008· article· en· Neurology· Medicine
aff
174
citations
Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
2015· article· en· Neurobiology of Disease· Medicine
fundno aff
162
citations
Convergence of Heat Shock Protein 90 with Ubiquitin in Filamentous α-Synuclein Inclusions of α-Synucleinopathies
2006· article· en· American Journal Of Pathology· Medicine
affno abstract
162
citations
TheFGF14F145SMutation Disrupts the Interaction of FGF14 with Voltage-Gated Na+Channels and Impairs Neuronal Excitability
2007· article· en· Journal of Neuroscience· Biochemistry, Genetics and Molecular Biology
aff
158
citations
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications
2009· article· en· Biochemical and Biophysical Research Communications· Medicine
affno abstract
158
citations
GBA-Associated Parkinson’s Disease and Other Synucleinopathies
2018· review· en· Current Neurology and Neuroscience Reports· Medicine
affno abstract
158
citations
Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice
2015· article· en· Antioxidants and Redox Signaling· Medicine
fundno aff
153
citations
Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease
2010· article· en· Molecular Neurodegeneration· Medicine
afffund
148
citations
Ubiquitination of α-Synuclein Is Not Required for Formation of Pathological Inclusions in α-Synucleinopathies
2003· article· en· American Journal Of Pathology· Medicine
fundno affno abstract
140
citations