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Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
Non-randomized trialObservational
Classifier consensus
Observational
Teacher imitation scores

Codex

Observational0.998
Bench or experimental0.011
Metaresearch0.003
Other design0.002
Randomized trial0.001
Meta-epidemiology (broad)0.000
Meta-analysis0.000
Case report0.000
Not applicable0.000
Open science0.000
Research integrity0.000
Qualitative0.000
Non-randomized trial0.000
Bibliometrics0.000
Simulation or modelling0.000
Scholarly communication0.000
Meta-epidemiology (narrow)0.000
Science and technology studies0.000
Systematic review0.000
Theoretical or conceptual0.000

Gemma

Observational1.000
Bench or experimental0.002
Non-randomized trial0.001
Not applicable0.001
Randomized trial0.001
Meta-analysis0.001
Case report0.000
Metaresearch0.000
Simulation or modelling0.000
Research integrity0.000
Meta-epidemiology (broad)0.000
Meta-epidemiology (narrow)0.000
Open science0.000
Bibliometrics0.000
Science and technology studies0.000
Qualitative0.000
Scholarly communication0.000
Systematic review0.000
Theoretical or conceptual0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.028
GPT teacher head0.269
Teacher spread
0.241 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

Isolated rapid-eye-movement (REM) sleep behaviour disorder (IRBD) can be part of the prodromal stage of the α-synucleinopathies Parkinson's disease and dementia with Lewy bodies. Real-time quaking-induced conversion (RT-QuIC) analysis of CSF has high sensitivity and specificity for the detection of misfolded α-synuclein in patients with Parkinson's disease and dementia with Lewy bodies. We investigated whether RT-QuIC could detect α-synuclein in the CSF of patients with IRBD and be used as a bio…

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