Antimicrobial Properties of Graphene Oxide Nanosheets: Why Size Matters
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Résumé
Graphene oxide (GO) is a promising material for the development of antimicrobial surfaces due to its contact-based antimicrobial activity. However, the relationship between GO physicochemical properties and its antimicrobial activity has yet to be elucidated. In this study, we investigated the size-dependency of GO antimicrobial activity using the Gram-negative bacteria Escherichia coli. GO suspensions of average sheet area ranging from 0.01 to 0.65 μm(2) were produced and their antimicrobial activity evaluated in cell suspensions or as a model GO surface coating. The antimicrobial activity of GO surface coatings increased 4-fold when GO sheet area decreased from 0.65 to 0.01 μm(2). The higher antimicrobial effect of smaller GO sheets is attributed to oxidative mechanisms associated with the higher defect density of smaller sheets. In contrast, in suspension assays, GO interacted with bacteria in a cell entrapment mechanism; in this case, the antimicrobial effect of GO increased with increasing sheet area, with apparent complete inactivation observed for the 0.65 μm(2) sheets after a 3 h exposure. However, cell inactivation by GO entrapment was reversible and all initially viable cells could be recovered when separated from GO sheets by sonication. These findings provide useful guidelines for future development of graphene-based antimicrobial surface coatings, where smaller sheet sizes can increase the antimicrobial activity of the material. Our study further emphasizes the importance of an accurate assessment of the antimicrobial effect of nanomaterials when used for antimicrobial surface design.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
La notice
- Revue
- ACS Nano
- Thématique
- Graphene and Nanomaterials Applications
- Domaine
- Engineering
- Établissements canadiens
- —
- Organismes subventionnaires
- Natural Sciences and Engineering Research Council of CanadaConselho Nacional de Desenvolvimento Científico e Tecnológico
- Mots-clés
- AntimicrobialGrapheneSonicationMaterials scienceNanotechnologyNanomaterialsOxideCoatingChemistryChemical engineeringOrganic chemistryChromatography
- Résumé présent dans OpenAlex
- oui