Natural Products and Dermatological Hypersensitivity Diseases

In children with a family history of atopic diseases, research has been focused towards the effects of maternal diet during pregnancy, lactation, and then subsequently in the infant when and which foods are introduced.Of particular interest is the effect of probiotics on the development of allergies which will be discussed below (section 4.2.4).In patients with food allergies triggers are eliminated from the diet, however other foods have been suggested which might be beneficial to allergy suffers.Some of these compounds include poly-unsaturated fatty acids (PUFA); Vitamins C (Chang et al., 2009), D, E, Zinc, Selenium.However, these findings have been meet with mixed results (Finch et al., 2010). Medical treatmentMedical treatments are initiated as the severity of symptoms become worse and the disease becomes intolerable (Schmitt et al., 2008).For each condition, drug classes have been recommended to be added in a specific order/time in the treatment schedule.However, due to the nature of these conditions treatment is individually tailored depending on patient response and their tolerance of the side effects.These patients follow a defined treatment plan consisting of pharmacological classes, based on their indications and complications.When treatment is initiated for a patient, the success of treatment always needs to balance with the side effect the treatment has on patient quality of life.(R. Finkel et al., 2009).The following is a brief overview of some conventional treatments for hypersensitivity disease such as sterioids and anti-histamines.Some of these compounds originated from natural sources but have been modified extensively to improve both their efficacy and potency.As such, these medications are not strictly considered "naturally sourced."In section 3 below, we will address "naturally sourced" treatments for comparison. CorticosteroidsCorticosterioids are a class of steroid hormones that are frequently used as a first line treatment in many immunological and dermatological diseases (Richard Finkel, 2009).They can be classified as short to long acting (1-55+ hours) and are applied topically or systematically.They are very effective at mitigating inflammation; however, their side effects limit their long term use.Many of the new treatments are being sought as corticosteroids sparing alternatives (Del Rosso & Friedlander, 2005).Mechanism of Action: Corticosteroids bind intracellular receptors forming dimers that bind to the glucocorticoid response element of the promoter region of steroid responsive genes, which up regulates 10-100 genes (Bolognia et al., 2008).They also act by inhibiting nuclear factor kB (NF-κB) which dramatically decreases the inflammatory response through the down regulation of certain cytokines, cell adhesion molecules and other inflammatory mediators.(Ex: TNFα, GM-CSF, several interleukins (ex.Il-1, IL-2, IL-6, Il-8); Intercellular adhesion molecule-1 and E-selectin; cyclooxygenase, etc).(D'Acquisto et al.,

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