Carbon‐based compounds emerging as sparkling diamonds for IBS treatment? authors’ reply
Notice bibliographique
Résumé
Sirs, We read with interest the letter by Drs Chao and Holtmann on our study with AST-120 for the treatment of irritable bowel syndrome (IBS) symptoms.1 We agree that elimination of non-absorbable carbohydrates and polyols may induce benefit to IBS patients, although the number of IBS patients studied in a controlled study with such intervention remains low.2, 3 In the study with AST-120, patients with symptoms attributable to lactose maldigestion were excluded. Attempts to exclude other non-absorbable sugars and polyols were not specified, but we assume that the experienced clinicians took these types of dietary confounders into account. Fermentable oligo-, di- and monosaccharides and polyols have been implicated in worsening of abdominal pain, bloating and flatulence in IBS.2, 3 The same symptoms improved in our study with AST-120.4 The spectrum of molecules that AST-120 can bind is wide, and it is presently unclear whether this also involves (metabolites of) non-absorbable carbohydrates and polyols. The place of AST-120, relative to other available treatments for IBS, including dietary measures, requires additional (phase 3) studies. Drs Chao and Holtmann raise the issue of confounding by the intake of rescue medication. Loperamide was allowed as rescue therapy for diarrhoea, but its use throughout the study was very low, similar for both treatment groups, and it did not contribute to explaining the differences observed between active and placebo treatment. A final comment relates to the apparent loss of efficacy over placebo in the second half of the double-blind randomised phase of the trial. We think this effect is mainly due to a rise in placebo response, and may be due to the selection of patients that entered the trial, who were perhaps more prone to transient symptoms, as well as the relatively small sample size. Moreover, it is unclear whether patient’s expectations, in a trial design where they were guaranteed to receive active treatment during at least part of the study period, may have contributed to the rising placebo response. These issues will be addressed in subsequent studies. Declaration of personal interests: Dr Jan F. Tack has served as a consultant to Addex Pharma, Almirall, Aryx, AstraZeneca, Danone, Ipsen, Menarini, Movetis, Norgine, Novartis, NPS Pharma, Nycomed, Ocera, Rose Pharma, SK Life Sciences, Smartpill, Sucampo, Theravance, Tranzyme, Xenoport and Zeria Pharmaceutical Co. Dr. Philip B. Miner has served as a consultant to Abbott Laboratories, Altheus Therapeutics, Aryx Pharmaceuticals, AstraZeneca, Inc, Atlantic Pharmaceuticals, Inc, Axcan Pharmaceuticals, Biogen-Idec, Centocor Inc, Pozen Inc., Salix Pharmaceuticals, Sanofi-Aventis, Selexys Pharmaceuticals, Takeda Pharmaceutical Company, UCB Inc, Vecta Ltd and Ventrus Biosciences. He has received grant and research support from Abbott Laboratories, Aryx Pharmaceuticals, AstraZeneca, Inc, Axcan Pharmaceuticals, Biogen-Idec, Centocor Inc, Eisai Co Ltd., Forest Laboratories, GlaxoSmithKline, Lexicon Pharmaceuticals, Prometheus Laboratories, Pozen Inc., Salix Pharmaceuticals, Schering-Plough, Selexys Pharmaceuticals, Takeda Pharmaceutical Company, UCB Inc, Vecta Ltd, Ventrus Biosciences and Wyeth Laboratories (now Pfizer, Inc). Dr Laurent Fischer is an employee of Ocera Therapeutics. Dr M. Scott Harris has served as a consultant to Ocera Therapeutics, Inc., Meda Pharmaceuticals, Inc., Martek Biosciences, International Institute for One World Health, Ardelyx Pharmaceuticals, Theravance Inc., Tranzyme Pharmaceuticals, Combimab Pharmaceuticals, UCB Inc., Kala Pharmaceuticals, Orchid Pharmaceuticals, Radiation Control Technologies, Inc and Napo Pharmaceuticals. He has received grant and research funding from Meda Pharmaceuticals and owns stock and shares in Ocera Therapeutics, Inc and Napo Pharmaceuticals. He was an employee of Ocera Therapeutics during the conduct of this trial. Declaration of funding interests: None.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,007 | 0,031 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,002 | 0,002 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,002 | 0,003 |
| Communication savante | 0,003 | 0,007 |
| Science ouverte | 0,003 | 0,002 |
| Intégrité de la recherche | 0,026 | 0,039 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,005 | 0,004 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».