The Role of Cellular Differentiation and Cell Fate in Malignant Melanoma
Notice bibliographique
Résumé
1.1 Defining differentiation and cell fate in cancer In the setting of embryonic development, terms such as “cell fate“ and “cellular differentiation“ are relatively easy to grasp, since they refer to a straightforward linear model whereby progenitor cells give rise sequentially to various distinct and identifiable lineages, eventually resulting in a terminally differentiated cell that has until recently been thought to possess very little cellular plasticity or multipotent capacity. The sequences of events that regulate this process are extremely well conserved within a species, and even across species in many instances. In the setting of cancer, cell fate and cellular differentiation are often used descriptively to convey an observed phenotype rather than a defined and well-understood molecular process. How accurate is it to refer to “differentiation“ in cancer when the so-called end-point for this process results in cellular heterogeneity that is antithetical to the regulated and predictable differentiated cells that result from embryonic development? What does it mean to refer to “cell fate“ during the inherently dysregulated series of events involved in oncogenesis, which may not result in a distinct endpoint even across cells within the same tumor? Our review uses these terms in reference to the dynamic processes that constantly shape the function and properties of melanoma cells, which coincidentally utilize many of the same pathways involved in the regulated process of differentiation and determination of cell fate during embryonic development. While the label of being a differentiated cell may imply a terminal nature that might be viewed as less tumorigenic or lethal in the setting of cancer, this concept requires further experimental confirmation. Undoubtedly, these terms will become more refined as our understanding of the molecular events underlying melanoma progression comes into clearer focus. For now, they are the best terms available to describe some of the events and processes that help determine the behavior and response of tumor cells, and we use them with the full knowledge that years from now, advances in our understanding of cancer could render these terms woefully inadequate, or worse yet inaccurate.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».