Technetium: Organometallic ChemistryBased in part on the article Technetium: Organometallic Chemistry by Ronald J. Clark which appeared in the <i>Encyclopedia of Inorganic Chemistry, First Edition</i> .

Abstract The chemistry of organometallic technetium compounds is discussed along with its application in the field of nuclear medicine. Several 99m Tc radiopharmaceuticals are presently used in hospitals using a 99 Mo− 99m Tc generator to prepare the starting material [ 99m TcO 4 ] − . The isotope 99m Tc is a γ‐ray emitter. The most common organometallic radiopharmaceutical is [Tc(MIBI) 6 ] + , where MIBI is an isonitrile ligand. 99m Tc can be produced only at the tracer level and it disintegrates to the longer life isotope 99 Tc, which has a half‐life of 2.12 × 10 5 years. The chemistry of technetium has been studied with the latter isotope, which is commercially available. But it emits weak β − particles and special precautions must be taken in the laboratories in order to avoid health problems. Most of the publications in the literature on organometallic Tc compounds contain the ligands CO, isonitriles or the cyclopentadienyl ion. These π‐accepting ligands usually bind to Tc in a low oxidation states. Tc‐CO compounds are the ones who have been most studied. Binary compounds and a great variety of mixed‐ligands complexes are discussed. The new complex ion [Tc(CO) 3 (H 2 O) 3 ] + is particularly important, since a kit was recently developed for its preparation. It should open a new field for the development of 99m Tc radiopharmaceuticals. It can bind to biomolecules like proteins, peptides, and antibodies which have very specific targets. Several Tc‐cyclopentadienyl complexes have the sandwich or the piano stool structures. The arene compounds should have similar structures, but the latters have not been much studied yet. No Tc‐arene compound seem to have been characterized by crystallographic methods yet. But more recently, interest in the arene complexes has increased because of its potential use in nuclear medicine. Isonitriles or isocyanides and cyanide ligands are bonded to Tc through the C atom. A few crystal structures on mixed‐ligand isonitrile Tc complexes were determined and the segment TcCNC is linear. Fewer cyanide Tc compounds were studied. Finally a few Tc‐alkyl compounds have been reported.

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