Abstract P3-07-01: Circulating vitamin D concentrations and breast cancer risk: A pooled analysis of 17 cohorts
Notice bibliographique
Résumé
Abstract Optimizing vitamin D status through the use of supplementation and/or judicious sun exposure has been proposed as a BC risk reduction strategy. This simple and non-invasive approach to BC prevention is extremely appealing given that vitamin D concentrations in circulation are low in many individuals around the world. However, an Institute of Medicine (IOM) report found the evidence on vitamin D and breast cancer to be inconsistent. To clarify the relationship between vitamin D and breast cancer, data was pooled on approximately 25,000 women from 17 prospective cohorts worldwide. The association between pre-diagnostic circulating 25(OH)D levels, the accepted measure of vitamin D status, and breast cancer incidence was examined. For five cohorts, vitamin D status was assessed at a central laboratory (Heartland Assays, Inc.) using a direct, competitive chemiluminescence immunoassay that measures 25(OH)D2 and 25(OH)D3 equivalently. In 12 cohorts with previously measured 25(OH)D levels, a stratified sample of 29 controls was re-assayed at Heartland Assays and used to calibrate existing levels to a central assay using robust linear regression analyses. We standardized 25(OH) D levels for season using a periodic sine/cosine function. Conditional logistic regression analyses were performed in each study and were then pooled to generate pooled odds ratios by study-specific quantiles, consortium wide-quantiles, absolute cut points based on IOM guidance. Our preliminary analyses included 10,353 cases of incident invasive breast cancer (5305 estrogen receptor (ER) positive cases and 1311 (ER) negative cases and 12,313 matched controls. Median calibrated 25(OH)D levels in controls varied from 33 to 70 nmol/L across the cohorts. The consortium-wide median 25(OH)D among controls was 22% higher in summer as compared to winter months. Across all studies, median age at blood draw was 41 to 70 years; and median elapsed time from blood draw to diagnosis ranged from 2 to 13 years. The pooled odds ratio of breast cancer, comparing the highest to lowest study-specific 25(OH)D quintile, was 0.99 (95% confidence interval 0.90-1.08) after adjusting for body mass index, physical activity, menopausal status, menopausal hormone therapy use, parity/age at first birth, and family history of breast cancer. Results were not significantly different in analyses stratified by age of diagnosis (<50, 50-60, 60+ y).or by ER status. When calibrated circulating 25(OH)D levels were categorized based on the IOM definitions of "deficiency", "inadequacy", "adequacy", and "beyond adequacy", risk was similar across the categories. Further analyses are ongoing to examine especially low and high 25(OH)D concentrations, whether the vitamin D association varies according to tumor characteristics, the importance of elapsed time between blood draw and diagnosis. These will be completed before the meeting. In conclusion, preliminary results from the largest pooled analysis of prospective studies to date show no association between 25(OH)D levels and breast cancer risk and therefore suggest that increasing Vitamin D levels may not be an effective risk reduction strategy for breast cancer. Citation Format: Kala Visvanathan, Alison Mondul, Anne Zeleniuch-Jacquotte, Toqir K Mukhtar, Stephanie A Smith-Warner, Regina G Ziegler, On Behalf of Investigators in the Vitamin D Pooling Project of Breast and Colorectal Cancer. Circulating vitamin D concentrations and breast cancer risk: A pooled analysis of 17 cohorts [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P3-07-01.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,010 | 0,012 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,003 | 0,009 |
| Bibliométrie | 0,002 | 0,003 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».