Notice bibliographique
Résumé
Cardiovascular disease remains the major cause of morbidity and mortality; according to statistics, heart failure, the syndrome consequential to many diseases of the cardiovascular system, is estimated to have a prevalence of 1-2% and an annual incidence of 5-10 per 1,000 in the developed countries and is the leading cause of hospitalization in the population over 50 years of age. Worse so, there is a clear tendency of increasing prevalence of cardiovascular disease in this planet particularly in the developing nations. This problem casts enormous health concern and costly socioeconomic burden worldwide. We have entered post-genome era after the human genome project had been completed years ago. Only <2% of all transcribed bases of the entire human genome constitutes the genetic sequence encoding proteins and the rest of 98% accounting for ~70% of all genes carry the sequences for RNAs not encoding a polypeptide chain that was used to be considered for many years "junk DNA" of no physiologic function; proteins were generally assumed the sole biopolymer capable of regulatory function. Intriguinly, the proportion of transcribed non-protein-coding sequences increases with developmental complexity and is a better indicator of phylogenetic level than the number of protein-coding genes of an organism. It is now known that "junk DNA" encodes non-protein-coding RNAs (ncRNAs) that are involved in determining the expression of protein-coding genes by regulating the activity of that 2% of the genome. These ncRNAs include microRNAs (miRNAs), once ignored completely or overlooked as cellular detritus, which were discovered over a decade ago have recently taken many by surprise because of their widespread expression and diverse functions. miRNAs are endogenous small mRNAs of ~22 nucleotide in length which act primarily to repress gene expression at the post-transcriptional level. To date, ~6400 vertebrates mature miRNAs have been registered in miRBase, an online repository for miRNA, among which ~5100 miRNAs are found in mammals which include >850 human miRNAs. These miRNAs are predicted to regulates >60% of protein-coding genes. The discovery of miRNA challenges the central dogma of molecular biology that has be hold since the latter half of the 20th century. With the recent rapid evolution of miRNA research, researchers have begun to appreciate the roles of these small non-protein-coding mRNAs in the cardiovascular system. Based on the published studies, it is now clear that miRNAs are involved in nearly all aspects of cardiac function and pathogenesis
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».