AB 12. Chronomodulated chemotherapy in chemo naïve NSCLC patients
Notice bibliographique
Résumé
BACKGROUND: Lung cancer treatment efficiency has reached a plateau during the last decade. Although targeted therapies according to tumors biology and genome expression (pharmacogenomics) have been introduced in the standard care or are under investigation. Therefore new methods of chemotherapy treatment have been investigated in order to augment the efficiency of the already well-established cytotoxic regimens. PATIENTS AND METHODS: Twenty non-small cell lung cancer (NSCLC) chemo naïve patients stage IV were included in the protocol. Sleep disorders were measured with questionnaires (FSS, MRC, Pittsburgh, and ESS), polysomnography and actigraphy for 3 consecutive days. The actigraphy (actiwatch spectrum, Philips, Respironics) was initiated 1 day before treatment when the patient was still at home, the second day when the patient received the platinum analogue doublet and during the 3 day where the patient was still hospitalized for follow up. Laboratory values of ACTH, adrenaline, nor-adrenaline, saliva cortisol (4 measurements/day), morning cortisol and DPD enzyme were collected and measured for 3 consecutive days. The measurements were reevaluated after 3 cycles of chemotherapy. RESULTS: Twenty NSCLC patients entered the protocol and received a doublet of platinum analogue and docetaxel. Two patients were excluded from the protocol since they did not wear the actigraph spectrum watch the proper hours indicated by the treating physicians. No severe hematological toxicity grades 3 or 4 (according to the National Cancer Institute of Canada Common Toxicity Criteria version 3) were observed. An objective tumor response according to the RECIST revised criteria version 1.1 was observed in 10/18 patients. Chronomodulated administration according to the circadian rhythm (rest of cell division of normal cells) is strongly associated with chemo-efficiency (P<0.001). A strong association was observed between circulating hormones and disease status (P<0.006). In addition, sleep disorders were associated with disease status (P<0.005) and normalized with efficient treatment (P<0.003). CONCLUSIONS: Chronomodulate chemotherapy administration is a method to augment the treatment efficiency, however expensive and difficult to perform. Key parameters such as expensive equipment and sleep expert pulmonary physicians are required.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».