The Study of Pharmacological Efficacy in Dry Mulberry Burirum-60 in MildStage of Alzheimer's Disease
Notice bibliographique
Résumé
Alzheimer’s Disease is a condition in which occurs in the area concerning the deteriation of brain function. This condition of disease is not completely curative treatment by medicines and always happens in the eldery with ages over 55 years old. However it can delay and maintain the condition of the stages of deteriation of brain function. In this experiment. We used Morus alba Linn. Burirum 60 leaves collected from Mahasarakham University Research Plantation Field, the Division of Research Innovation and were prepared as a powder in capsule form to control the incidence and maintain brain function condition in Mild stage of Alzheimer’s disease patients. Morus alba Linn. contains many minerals and vitamin A, vitamin B, vitamin B3, vitamin B12, vitamin C, essential amino acids, Zinc, Magnesium, Sodium, deoxynojirimycin, GABA, Phytosterol , Calcium, Potassium, folic acid etc.. The samples of this research were collected from silk weaving women, ages of 55-70 years old in Silk Innovation Weaving Village, supported by Mahasarakham University. The samples were divided into 4 groups as follows: group no.1 of feeding silkworms weaving women and intake Morus alba Burirum 60 capsule, group no.2 of feeding silkworms weaving women and intake placebo, group no.3 of non feeding silkworm weaving women and intake Morus alba Burirum 60 capsule, group no.4 of non feeding silkworms weaving women and intake the placebo. All samples were tested with Cognitive Testing Scale and the selected samples were Mild cognitive memory function group. The dosage of Morus alba capsule would have 2 capsules after meals , once daily for 3 months and all the samples were tested for cognitive memory function using the scales of Sage1, Mini-Mental state Examination (MMSE), Functional Assessment Stage tool (Fast) for evaluation and confirmation of the efficacy of Mulberry (Morus alba Burirum 60) effecting the brain function. The data were tested with Wilcoxon Signed Rank Test and Kruskal Wallis statistical analysis. The result revealed that each 4 groups of Group no.1, no.2, no.3, and no.4 were 3.00, 1.50, 3.00 and 2.00 respectively. It showed that in each group had indicated mean scores with statistical significant difference at p-value 0.05. It showed the development of changing scores tested by SAGE1 scale within the group. Then we compared the mean scores difference among or in between groups by using the Kruskal Wallis statistical method. The result found that the mean rank score among 4 groups before the experiment were 14.10, 12.70, 7.30 and 7.90 respectively and the mean rank score among 4 groups after the experiment were 17.70, 8.70, 11.00 and 4.60 respectively. The higher rank of each groups indicated the higher development in obtaining the scores of SAGE1 tested by Kruskal Wallis after the experiment by oral intake of Morus alba Linn. Burirum-60 capsules with the dosage of 200 mg daily for 3 months. It showed the development of cognitive memory function by increasing the ranking scores of group no.1, group no.3 and group no.2 respectively. The suggestion of this study for the future research is to increase the size of samples and clinical confirmed with CT-SCAN or NMR in order to measure the comparison of improvement in the density and brain image before and after the experiment and also the duration of administering or intake Morus alba Linn. Burirum-60 should be recommended to extend longer period of time and may be increase in the daily dosage. Key words: Mild cognitive memory impairment; MMSE; SAGE1; FAST; Alzheimer Disease
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,005 |
| Études des sciences et des technologies | 0,000 | 0,003 |
| Communication savante | 0,000 | 0,003 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».