Cancer stem cells in glioblastoma
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Résumé
Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and mimic their origins. Glioblastoma (GBM) is the most prevalent and malignant primary brain tumor and contains self-renewing, tumorigenic cancer stem cells (CSCs) that contribute to tumor initiation and therapeutic resistance. As normal stem and progenitor cells participate in tissue development and repair, these developmental programs re-emerge in CSCs to support the development and progressive growth of tumors. Elucidation of the molecular mechanisms that govern CSCs has informed the development of novel targeted therapeutics for GBM and other brain cancers. CSCs are not self-autonomous units; rather, they function within an ecological system, both actively remodeling the microenvironment and receiving critical maintenance cues from their niches. To fulfill the future goal of developing novel therapies to collapse CSC dynamics, drawing parallels to other normal and pathological states that are highly interactive with their microenvironments and that use developmental signaling pathways will be beneficial.
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La notice
- Revue
- Genes & Development
- Thématique
- Cancer Cells and Metastasis
- Domaine
- Medicine
- Établissements canadiens
- —
- Organismes subventionnaires
- National Institute of Neurological Disorders and StrokeCanadian Institutes of Health ResearchOhio Cancer ResearchCase Comprehensive Cancer Center, Case Western Reserve UniversityAmerican Cancer SocietyJames S. McDonnell FoundationComprehensive Cancer Center, City of HopeNational Cancer InstituteCleveland ClinicSontag FoundationVoices Against Brain CancerOhio Cancer Research AssociatesV Foundation for Cancer ResearchNational Institutes of Health
- Mots-clés
- BiologyCancer stem cellStem cellTumor initiationProgenitor cellGlioblastomaTumor microenvironmentCancer researchNeuroscienceCancerBrain tumorCell biologyCarcinogenesisTumor cellsGeneticsPathology
- Résumé présent dans OpenAlex
- oui