Modelagem farmacocinética e análise de sistemas lineares para a predição da concentração de medicamentos no corpo humano.
Notice bibliographique
Résumé
The pharmacokinetic modeling can predict the concentration of drug in different tissues of the human body.The development of mathematical models is an important tool to verify the appropriateness of certain procedures performed in medication administration.The objective of this work is to develop a pharmacokinetic model able to predict the plasma concentration of drug in the body after various forms of infusion.Two approaches were used.Initially, in the one-compartment approach it was considered that the drug enters the body directly into the blood compartment, which represents the entire human body.In the two-compartment approach it was considered the following compartments: one representing the means by which the drug is infused into the body (either via the gastrointestinal tract, lung, or transdermal) and one representing the blood plasma.In both cases, it was considered homogeneous concentration of the drug in the compartments.The model was built by using block diagrams and the solution was obtained using the Laplace Transform.The model was validated by comparing its results to literature data, with very good agreement.The model allowed comparing the one-compartment constant infusion of drug in the body with the periodic infusion.The analysis of the results generated by the model showed that the concentrations achieved by these methods are not the same.The two-compartment model allowed simulating oral and transdermal administration, and inhalation.It was possible to predict blood concentration after interruption of therapy with anti-depressants and anti-conceptional drugs.The model was able to verify the time it takes to reach the former level.Methods have been proposed to achieve the same concentration in a shorter period of time.Another application was the comparison of the treatment with whole tablets and taken by half in a smaller interval of time.It was found that the concentration achieved is different even though the same mass is ingested in both cases.The model was also used to calculate the concentration of nicotine after cigarette smoking and it was found that the individual who smokes every three hours, nicotine is not entirely eliminated from body.Furthermore, it was possible to simulate overdose of an anti-inflammatory and the period of time when the concentration is above the therapeutic level.It has been proposed a method to obtain pharmacokinetic parameter related to absorption, which can be easily obtained based on data present in the drug bull.This method is much simpler and more accurate than the method proposed in the, which uses graphical analysis and clinical data that are not so easy to be obtained.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,008 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,001 | 0,003 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,002 | 0,001 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,002 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,006 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».