Abstract B132: Risk factors for uncommon histologically defined subgroups of breast cancer using the Breast Cancer Family Registry
Notice bibliographique
Résumé
Abstract Breast cancer is a heterogeneous disease; risk factors may differ for histologically-defined subgroups. Because most breast cancers are of ductal or lobular histology, previous studies have been limited in their ability to evaluate risk factors in rarer histologies, such as medullary, mucinous, and tubular, due to small sample sizes. We evaluated risk factors for histologically-defined breast cancer subgroups (ductal, lobular, tubular, medullary, or mucinous) using population-based data from the Breast Cancer Family Registry. Data were available for 3260 incident breast cancer cases (including 92 cases of medullary, 90 cases of mucinous, and 86 cases of tubular histology) and 2997 unrelated controls. Several reproductive factors were associated with the risk of mucinous breast cancer, whereas cigarette smoking and body mass index (BMI) were associated with the risk of medullary breast cancer. For the mucinous subtype, we observed positive associations with nulliparity (OR=2.54, 95%CI 1.17–5.50) and age at first birth (OR=1.08, 95%CI=1.02–1.14, for each additional year of age), and an inverse association with age at menarche (≥13 vs. ≤11) (OR=0.52, 95%CI 0.29–0.94). These reproductive factors were not associated with other histologic subtypes. Mucinous cases were less likely than controls to have used oral contraceptives (OC use ≤ 5 years: OR=0.50, 95%CI 0.28–0.92; OC use > 5 years, OR=0.45, 95%CI 0.24–0.84), and these findings did not differ by menopausal status. Oral contraceptive use was also inversely associated with tubular histology among premenopausal women only (OC use > 5 years, OR=0.35, 95%CI 0.14–0.87), but was not associated with other histologic subtypes when compared with controls. Medullary histology was inversely associated with smoking status (former smoker vs. never smoker, OR=0.30, 95%CI 0.14–0.62), and positively associated with BMI (OR=1.05, 95%CI 1.01–1.09, for each one-unit increase in BMI). Other known breast cancer risk factors, such as hormone-replacement therapy (HRT), breastfeeding history, and alcohol use, were not associated with the any of the rarer subtypes. Family history of breast cancer was associated with increased risk of all histologic subtypes. If replicated, these findings suggest different patterns for selected breast cancer risk factors, such as parity, oral contraceptive use, and smoking, by tumor histology. Citation Information: Cancer Prev Res 2010;3(1 Suppl):B132.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».