Improvement of LV functional performance in the chronic total coronary occlusion during the late stage is associated with the extensive collateral development
Notice bibliographique
Résumé
In nine pigs a CTO was created by percutaneously inserting a fibrin plug (AngiosealΤΜ) into the mid-to-distal left anterior descending artery (LAD). Animals were studied six (n=3) or twelve weeks (n=6) later prior to sacrifice. An x-ray angiogram confirmed the LAD CTO at those time points. Cardiac MR (CMR) studies were then conducted on a 1.5T (n=6) or on a 3.0T MRI system (n=3), which included SSFP short axis sections for wall motion and post-gadolinium LGE-MRIs for viability. After sacrifice, both right and left coronary systems were injected with Microfil. X-ray or MSCT angiography of the fixed heart was obtained. A longitudinal cardiac section including the CTO lesion, proximal/distal LAD and the borders of infarction was removed and prepared in gel, then imaged in a micro-CT system at 27 micron resolution. LV functional parameters including wall thickness at end-systole (WTES) and end-diastole (WTED) were measured in border zone, infarct and remote region. Systolic wall thickening (SWT) was calculated using as (WTES-WTED) x100/WTED. CMR and micro-CT data were processed using commercial software. The extent of collaterals on micro-CT images was rated qualitatively using a score from 0 to 3, indicating that no, minimal, moderate, or extensive collaterals were observed. A Student’s t-test was used for the statistical significance of differences between measurements at 6 and 12 weeks. LGE-MRI determined the presence of LV myocardial infarction (MI). Tables 1 and 2 summarize the results of global and regional LV function measurements at both time points. Ejection fraction (LVEF) at 12 weeks was significantly greater than at 6 weeks (39.45±5.38% vs. 26.27±5.77%, P=0.01) although the extent of infarct was similar between these two groups (P=0.16). In border zone the WTES (11.31±1.72 vs. 8.67±0.57mm, P=0.04) and SWT (68.31±11.55% vs. 35.87±19.14%, P=0.01) increased at 12 versus 6 weeks. On the visual scores of collateral development, between 6 and 12 weeks, there was an increase in collateral number (1.33±0.58 vs. 2.83±0.41, p<0.003). Figure 1 similarly illustrates increased collateral development at the later time point. Compared to the minimal collateral formation in the 6 weeks’ CTO animal (A-E), extensive collateral development was observed in the 12 weeks’ CTO animal (F-J), which is consistent with the increased systolic wall thickening and better LV function performance measured from cine SSFP images in the late stage of CTO. A, F: end-systolic SSFP images; B, G: end-diastolic SSFP images; C, H: LGE-MRI images; D, I: rotational x-ray angiogram; E, J: 3D micro-CT images reconstructed from highlighted box regions of D and I. Black, green and orange arrows indicating infarct, border and remote region. Extensive collateral development during the late stage of myocardial repair after CTO may contribute to LV functional improvement through increased SWT in the border zone. This provides a potential explanation for preserved LV function witnessed in some patients with CTO.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».