Cost-Effectiveness of Taxanes in the Treatment of Metastatic Breast Cancer: A Review of the Literature
Notice bibliographique
Résumé
Background/Aims: Metastatic breast cancer (MBC) is an incurable disease in which regardless of treatment, total survival time is often less than a year. In these patients suffering from MBC, mitigation of symptoms, reducing side effects of therapy and enhancing quality of life are the major issues in selecting a treatment. Taxanes have been shown to be efficacious as single agents or in combination with other agents as compared to other chemotherapy regimens. Docetaxel has received more support over paclitaxel in many analyses that have compared the two drugs indirectly. A direct comparison of both docetaxel and paclitaxel has not been possible until recently due to a lack of randomized trials. Little is known in reference to cost-effectiveness of taxanes in the treatment of MBC when compared directly. The objective of this literature review was to assess cost-effectiveness literature comparing docetaxel and paclitaxel in MBC. Methods: PubMed was used to conduct a search for manuscripts published 2005–2014. Search terms included “metastatic breast cancer” in addition to “cost-effectiveness” (n=96), “cost-utility” (n=9), “docetaxel” (n=332) and “paclitaxel” (n=336). Only articles that included cost-effectiveness analyses and a direct comparison among the taxanes were included. Results: A total of three cost-effectiveness studies were identified and included in the final review. Two of the three studies utilized data from a randomized controlled trial. The cost-effectiveness analyses reported incremental cost-effectiveness ratios (ICER) and quality adjusted life-years (QALY) and concluded that docetaxel, compared to paclitaxel, was superior and improved QALYs by 0.33–0.75. It is important to note that all three analyses were conducted outside of the United States. Discussion: In North America, breast cancer remains the most frequently diagnosed cancer in women. Yet, there are no new comprehensive economic analyses comparing the two taxanes published recently in the United States. Literature reflecting such comparisons has been published within the United Kingdom, Spain and Canada (reflected in this review). However, with the prevalence for the disease growing, it is important to continuously develop models assessing cost-effectiveness among patients with MBC.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,004 | 0,001 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».