RISK OF LUNG CANCER AND MESOTHELIOMA ASSOCIATED WITH OCCUPATIONAL EXPOSURE TO ASBESTOS
Notice bibliographique
Résumé
Most of the evidence about the risk of lung cancer and mesothelioma resulting from asbestos exposure comes from studies focusing on specific groups of workers with high exposure levels such as miners and asbestos textile workers. We present here results of our population-based case-control study of cancer and occupational exposures conducted in Montreal in the 1980s, thereby providing estimates of risks associated with exposure to asbestos incurred at various levels and over a wide range of occupations. Interviews were carried out with 3630 histologically-confirmed incident cancer cases (19 cancer sites), of whom 857 were lung cancers and 12 were mesotheliomas, and with 533 population controls. A detailed job history was obtained, as well as data on potential confounders. Each job held by each subject was evaluated by a team of chemists/hygienists and translated into a list of 300 potential exposures, including asbestos. In total, about 19% of study subjects had asbestos exposure. For each case series-lung cancer and mesothelioma, unconditional logistic regression analyses were performed using both the population controls (n = 533) and cancer control series (n = 1349 for lung cancer; n = 2860 for mesothelioma). Analyses focusing on lung cancer were adjusted for age, socio-economic status, respondent status, ethnicity and smoking as well as exposure to selected occupational carcinogens. Analyses focusing on mesothelioma were adjusted for age, socio-economic status and respondent status. For both lung cancer and mesothelioma, it turned out that results were similar using one or other control group; we present results using cancer controls. The odds ratio (OR) for lung cancer associated with exposure to asbestos was 1.1 (95% confidence interval [95%CI] = 0.8–1.5) for workers exposed at the non-substantial level and 1.9 (95%CI = 1.0–3.6) for those exposed at the substantial level. The OR for mesothelioma associated with non-substantial exposure to asbestos was 3.1 (95%CI = 0.8–12.3) and 15.0 (95%CI = 2.9–78.6) for exposure at the substantial level. All asbestos-exposed subjects were thought to have been exposed to chrysotile fibers. While it is difficult to ascertain, there was an attempt to identify the subset that had also been exposed to amphiboles. The subset thus earmarked experienced somewhat lower risk of lung cancer and higher risk of mesothelioma than the rest of the asbestos-exposed workers, but none of these differences (between amphibole-exposed and other asbestos-exposed workers) were significantly different. In conclusion, low levels of occupational exposure to asbestos were not associated with an excess risk of lung cancer while higher levels were. Excess risks of mesothelioma were manifest at low and high levels.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».