Influence of Previous Radiation Exposure on Pathologic Features and Clinical Outcome in Patients With Thyroid Cancer
Notice bibliographique
Résumé
OBJECTIVE: To determine whether previous radiation exposure to the head and neck is related to less favorable pathologic and clinical outcome in patients after surgical management of thyroid cancer. DESIGN: Retrospective chart review. SETTING: Academic teaching hospital (referral center). PATIENTS: All patients with diagnosed thyroid cancer who had been exposed to radiation before surgical treatment were retrospectively identified from the thyroid cancer database at our institution (1963-2007). One hundred twenty-five patients (95 women and 30 men) were included. Inclusion criteria included surgical treatment for thyroid cancer and a history of exposure to radiation at least 3 years before diagnosis of the disease. MAIN OUTCOME MEASURES: Pathologic features and data related to disease recurrence, distant metastasis, and survival. RESULTS: Mean (range) age at first exposure to radiation was 19.4 (1-65) years, and mean lag time to diagnosis of disease was 28.7 (3-60) years. Patients were treated surgically with either total or near-total thyroidectomy (83%) or partial or subtotal thyroidectomy (17%). Pathologic diagnoses included 111 papillary carcinomas (89%). Sixty-three percent of patients had multifocal disease, 12% had lymphovascular tumor invasion, and 26% had direct extrathyroid extension of disease. Twenty-five percent of patients had metastases to cervical lymph nodes, and 9% had distant metastases. Sixteen percent of patients experienced local recurrence of disease. At last follow-up, 86% of patients were alive and free of disease, 8% were alive with disease, 4% had died of thyroid cancer, and 2% had died of an unrelated cause. Compared with other patients with thyroid cancer, this radiation-exposed cohort was more likely to undergo total thyroidectomy, multiple operative procedures, and external radiotherapy. A higher percentage had multifocal disease, extrathyroid extension, stage IV disease, and distant metastases. At follow-up, fewer patients were free of disease, and more patients had died of thyroid disease. CONCLUSION: Patients who have been exposed to radiation have more aggressive disease and worse clinical outcome than other patients with thyroid cancer.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».