Notice bibliographique
Résumé
Back to table of contents Previous article Next article Clinical & Research NewsFull AccessAlzheimer's Drug Combo May Lower Nursing-Home CostsJoan Arehart-TreichelJoan Arehart-TreichelPublished Online:6 Jan 2012https://doi.org/10.1176/pn.47.1.psychnews_47_1_9-aAbstractWhen Alzheimer's patients receive a cholinesterase inhibitor such as donepezil, rivastigmine, or galantamine, it can delay the need to place them in a nursing home. And when they receive the NMDA receptor antagonist memantine plus a cholinesterase inhibitor, it can delay this placement even longer.These findings, by O.L. Lopez, M.D., a professor of neurology at the University of Pittsburgh, and colleagues have since been replicated by other researchers in North America and Europe, Lopez told Psychiatric News.Thus, if the use of memantine plus a cholinesterase inhibitor can delay nursing-home placement longer than the use of a cholinesterase inhibitor alone, can it also save money?The answer is yes, Jean Lachaine, Ph.D., an associate professor of pharmacy at the University of Montreal, and colleagues reported in the October 2011 Canadian Journal of Psychiatry.Specifically, it can save about $21,000 per patient annually (in either Canadian or American dollars) from a societal perspective, and about $31,000 per patient annually from a health care system perspective.Therefore, "the use of memantine, combined with a cholinesterase inhibitor, to treat Alzheimer's is a cost-effective alternative, compared with the use of a cholinesterase inhibitor alone," they concluded.In this analysis, they used data published by Lopez and his group as well as health care cost data published by Canadian researchers, including a large-scale Canadian epidemiologic study called the Canadian Study of Health and Aging, which is the primary reference for the costs of Alzheimer's in Canada. The costs considered included items such as medications, patient care in the community or by home health aid workers, lost productivity of caregivers due to time spent caring for patients, and nursing home costs. The costs were adjusted to 2010 values using the Canadian Consumer Price Index.Lachaine and his colleagues also found, as other researchers have, that placing Alzheimer's patients in a nursing home represents the largest cost component of managing their care.Lachaine and his colleagues either work for Lundbeck Inc. or consult to it. Lundbeck markets drugs for the treatment of Alzheimer's, as well as for other neurological or psychiatric conditions.An abstract of "Economic Evaluation of the Impact of Memantine on Time to Nursing Home Admission in the Treatment of Alzheimer Disease" is posted at http://publications.cpa-apc.org/media.php?mid=1232. ISSUES New Archived
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,002 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; les deux têtes enseignantes s’accordent sur ce qui est montré ici.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».