Abstract 169: Temporal trends, predictors, and outcome of chemotherapy in elderly women with advanced stage endometrial cancer.
Notice bibliographique
Résumé
Abstract Objective. Randomized clinical trials have suggested that adjuvant chemotherapy improves survival for women with advanced stage (III-IV) endometrial cancer. Despite the fact the endometrial cancer is common in the elderly, a minority of women >65 years of age were represented in these trials. We performed a population-based analysis to determine the use and impact on survival of adjuvant chemotherapy in elderly women with advanced stage endometrial cancer. Methods. The Surveillance Epidemiology, and End Results (SEER)-Medicare database was utilized to identify women diagnosed with stage III-IV endometrial cancer diagnosed from 1998-2007. Only those patients who had undergone a hysterectomy were included. The use of chemotherapy within 6 months of diagnosis and its impact on survival was examined using multivariable logistic regression and Cox proportional hazards models. Results. A total of 1819 women including 1193 with stage III and 626 with stage IV tumors were identified. Adjuvant chemotherapy was given to 46% of women. Use of chemotherapy increased with time from 42% in 1998 to 63% in 2007 (P<0.0001). By 2007, 54% of women with endometrioid tumors, 82% with serous tumors and 80% with carcinosarcomas received adjuvant chemotherapy. Use of whole pelvic radiotherapy decreased slightly from 40% in 1998 to 37% in 2007 while use of brachytherapy was stable at 22%. In a multivariable regression model, later year of diagnosis, non-endometrioid histology, residence in the eastern U.S., and stage IV disease were associated with receipt of chemotherapy while older women were less likely to receive chemotherapy (P<0.05). In a multivariable model including clinical and demographic characteristics women who received chemotherapy, mortality was reduced by 17% (HR=0.83; 95% CI, 0.72-0.96) compared to those who did not receive chemotherapy. Conclusion. Although the use of chemotherapy for elderly women with advanced stage endometrial cancer is increasing, fewer than half of patients >65 years of age receive chemotherapy. In addition to year of diagnosis, stage and histology are the strongest predictors of receipt of chemotherapy. Among elderly women with endometrial cancer, chemotherapy is associated with a reduction in mortality. Citation Format: Gunjal Garg, Zainab Siddiq, Gongfu Zhou, Matthew A. Powell, Thomas Herzog, David G. Mutch, Jason D. Wright. Temporal trends, predictors, and outcome of chemotherapy in elderly women with advanced stage endometrial cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 169. doi:10.1158/1538-7445.AM2013-169
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».