CEACAM1 (CD66a) Promotes Human Monocyte Survival via a Phosphatidylinositol 3-Kinase- and AKT-dependent Pathway

CEACAM1 (also known as CD66a) is a transmembrane glycoprotein that mediates homophilic intercellular interactions that influence cellular growth, immune cell activation, and tissue morphogenesis. Various studies have suggested a link between CEACAM1 and cellular apoptosis, including a recent demonstration that ERK1/2 signaling is triggered downstream of CEACAM1. In this study, we reveal that CEACAM1-long binding confers survival signals to human peripheral blood mononuclear cells. CEACAM-specific antibodies effectively protected peripheral blood mononuclear cells from apoptosis, with this effect being particularly dramatic for primary monocytes that undergo spontaneous apoptosis during in vitro culture. This protective effect was reiterated when using to CEACAM1 homophilic survival with a of cellular of apoptosis and of CEACAM1 binding triggered a of of effectively protective effect of CEACAM1. this that CEACAM1 confers a and survival that apoptosis of and CEACAM1 as a of of cell and CEACAM1 (also known as CD66a) is a transmembrane glycoprotein that mediates homophilic intercellular interactions that influence cellular growth, immune cell activation, and tissue morphogenesis. Various studies have suggested a link between CEACAM1 and cellular apoptosis, including a recent demonstration that ERK1/2 signaling is triggered downstream of CEACAM1. In this study, we reveal that CEACAM1-long binding confers survival signals to human peripheral blood mononuclear cells. CEACAM-specific antibodies effectively protected peripheral blood mononuclear cells from apoptosis, with this effect being particularly dramatic for primary monocytes that undergo spontaneous apoptosis during in vitro culture. This protective effect was reiterated when using to CEACAM1 homophilic survival with a of cellular of apoptosis and of CEACAM1 binding triggered a of of effectively protective effect of CEACAM1. this that CEACAM1 confers a and survival that apoptosis of and CEACAM1 as a of of cell and cell known as and is a and glycoprotein of of a from to and a a homophilic intercellular binding that a of cellular to cellular cell in is of and and and of of human cells and in is a of cell including and cells. 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