140 Open Label Pilot Study of Prolonged Release Nanocrystalline Silver Dressing (Acticoat 7): Reduction of Bacterial Burden Treatment in the Treatment of Chronic Venous Leg Ulcers
Notice bibliographique
Résumé
In persons with venous ulcers and an absence of arterial disease, high compression as exemplified by the four layer bandage (Profore) has been demonstrated to be effective by a meta-analysis of existing studies. Despite optimized compression, some venous ulcers do not heal at the expected rate and persistent inflammation or infection may delay or prevent healing. We report the results of a case series that demonstrates an ionized silver dressing with prolonged release of nanocrystalline crystals (Acticoat 7) can decrease bacterial burden and accelerate healing in venous ulcers not healing at the expected rate. Patients with venous ulcers were treated with a prolonged release absorptive nanocrystalline silver dressing (Acticoat 7) under a four layer bandage (Profore) for 12 weeks, or until healing. The primary efficacy objective measured the effect of the silver dressing on the wound microflora. Biopsies of the wounds were taken at baseline and after treatment with the silver dressing (Acticoat 7) and were analyzed for the bacterial species and number of bacteria present. In addition, serum silver levels were assessed at baseline, weeks 4, 8 and week 12 or final assessment. A total of 15 patients (9 male, and 6 female) were enrolled into the study. The median age was 63 years (range 30–83 years). The median duration of current ulceration was 17.3 weeks (range 4 weeks to 11 years) and the median ulcer area was 4.8 cm2(range 1.8–43.9 cm2). The median exposure to Acticoat 7 was 82 days (range 8–86 days). There was a statistically significant reduction (p = 0.0114) in the log10(total bacterial count) between the baseline and final biopsies (median 4.48 and 3.00, respectively). Four patients healed, 8 patients continued to the end of the 12-week study period and three patients were discontinued early. Of those patients who did not heal, 4 had more than a 94% reduction in wound area by the end of the 12-week study period. For all patients, the median percentage reduction in ulcer area was 94.4% and the median final ulcer area was 0.4 cm2. Statistical analysis showed a significant increase (p = 0.054) in serum silver concentration during the treatment period. At baseline, prior to the silver dressing treatment (Acticoat 7), the median silver concentration was 0.3 μg/L (range: 0.20–1.90 μg/L). The median within patient change from baseline serum silver concentration was an increase of 0.15 μg/L (range: −0.3–2.8 μg/L). Although this small increase was observed it was not considered clinically significant. This study illustrates the use of prolonged release nanocrystalline silver dressing to decrease the bacterial burden of chronic venous ulcers not healing at the expected rate.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».